88669-91-4

Upstream product

• 88669-88-9 (2S,5R,6S)-2-(1-Benzyl-1H-tetrazol-5-yl)-6-((R)-1-hydroxy-ethyl)-1-aza-bicyclo[3.2.0]heptane-3,7-dione 
• 2524-64-3 chlorophosphoric acid diphenyl ester 
• 64953-18-0 (1-benzyl-1H-tetrazol-5-yl)-acetic acid 
• 88669-86-7 (3S,4R)-4-[3-(1-Benzyl-1H-tetrazol-5-yl)-3-diazo-2-oxo-propyl]-3-((R)-1-hydroxy-ethyl)-azetidin-2-one 
• 88669-84-5 (3S,4R)-4-[3-(1-Benzyl-1H-tetrazol-5-yl)-2-oxo-propyl]-3-((R)-1-hydroxy-ethyl)-azetidin-2-one 
• 88669-72-1 ethyl (1-benzyl-1H-tetrazol-5-yl)acetate 
• 88669-70-9 (3S,4R)-3-<(1R)-1-<(tert-Butyldimethylsilyl)oxy>ethyl>-4-(carboxymethyl)azetidin-2-one 
• 100-39-0 benzyl bromide 
• 88669-71-0 (3S,4R)-4-[3-(1-Benzyl-1H-tetrazol-5-yl)-2-oxo-propyl]-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-azetidin-2-one 

Downstream Products

• 88669-99-2 {2-[(5R,6S)-2-(1-Benzyl-1H-tetrazol-5-yl)-6-((R)-1-hydroxy-ethyl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-en-3-ylsulfanyl]-ethyl}-carbamic acid 4-nitro-benzyl ester 
• 88669-92-5 (5R,6S)-2-(1-Benzyl-1H-tetrazol-5-yl)-6-((R)-1-hydroxy-ethyl)-3-phenylsulfanyl-1-aza-bicyclo[3.2.0]hept-2-en-7-one 

Relevant academic research and scientific papers

Total Synthesis of 3-(5-Tetrazolyl)carbapenems

The synthesis of the title compounds, β-lactam antibiotics, is described.A new tetrazole protecting group, (((p-nitrobenzyl)carbonyl)oxy)methyl, was succesfully applied.Substitution of carboxyl by tetrazole on the carbapenem nucleus results in stability to a degradative renal enzyme.