88673-81-8Relevant academic research and scientific papers
Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase
Antczak, Christophe,Shum, David,Bassit, Bhramdeo,Frattini, Mark G.,Li, Yueming,Stanchina, Elisa De,Scheinberg, David A.,Djaballah, Hakim
supporting information; experimental part, p. 4528 - 4532 (2011/09/12)
Selective inhibitors of human peptide deformylase (HsPDF) are predicted to constitute a new class of antitumor agents. We report the identification of benzofuran-4,5-diones as the first known selective HsPDF inhibitors and we describe their selectivity pr
BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS
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Page/Page column 114; 120; 121, (2010/11/18)
The instant invention provides novel benzofuran-4,5-diones and pharmaceutical compositions thereof useful for inhibiting PDF and for treating proliferative and infectious diseases. Compounds may be selective for eukaryotic (e.g., human) PDF or prokaryotic PDF
Halogenation and Nitration of 3-Acyl-5-hydroxy(acetoxy)benzofurans
Grinev, A. N.,Mukhanova, T. I.,Zinov'eva, R. A.,Alekseeva, L. M.
, p. 1044 - 1046 (2007/10/02)
Depending on the reaction conditions, the bromination of 3-acyl-5-hydroxybenzofurans leads to 4-bromo- and 4,6-dibromo derivatives, whereas chlorination leads to replacement of the hydrogen atom in the 4 position.As in the nitration of 3-acyl-5-hydroxyben
