886762-39-6

Basic information

• Product Name: 3,4-Dichloro-2-fluoroaniline
• Synonyms: 3,4-Dichloro-2-fluoroaniline
• CAS NO: 886762-39-6
• Molecular Formula: C₆H₄Cl₂FN
• Molecular Weight: 180.01
• Mol File: 886762-39-6.mol

Chemical Properties

• Boiling Point: 256℃
• Flash Point: 109℃
• Appearance: /
• Density: 1.502
• Vapor Pressure: 0.016mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: 2-8°C(protect from light)
• PKA: 1.51±0.10(Predicted)
• CAS DataBase Reference: 3,4-Dichloro-2-fluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dichloro-2-fluoroaniline(886762-39-6)
• EPA Substance Registry System: 3,4-Dichloro-2-fluoroaniline(886762-39-6)

Safety Data

• Hazard Codes: Xi
• RIDADR: UN2810
• Hazardous Substances Data: 886762-39-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3,4-Dichloro-2-fluoroaniline is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with specific therapeutic properties, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 3,4-Dichloro-2-fluoroaniline serves as an essential building block for the creation of novel agrochemicals. Its incorporation into these compounds can enhance their effectiveness in pest control and crop protection, thereby supporting sustainable agriculture.
Used in Dye Industry:
3,4-Dichloro-2-fluoroaniline is utilized as a precursor in the production of dyes. Its distinctive molecular structure contributes to the development of dyes with specific color properties and improved performance characteristics, meeting the diverse requirements of various industries.
Used in Organic Synthesis and Chemical Research:
3,4-Dichloro-2-fluoroaniline is employed as a versatile building block in organic synthesis and chemical research. Its unique functional groups and reactivity make it a valuable component in the development of new organic compounds and the exploration of novel chemical reactions.

InChI:InChI=1/C6H4Cl2FN/c7-3-1-2-4(10)6(9)5(3)8/h1-2H,10H2

Upstream product

• 17700-09-3 4-nitro-1,2,3-trichlorobenzene 
• 87-61-6 1,2,3-trichlorobenzene 

Downstream Products

• 1429757-65-2 4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-ol 

Relevant articles and documents

Preparation method of 3, 4-dichloro-2-fluoroaniline

The invention discloses a preparation method of 3, 4-dichloro-2-fluoroaniline, which comprises the following steps: (1) taking 1, 2, 3-trichlorobenzene as a raw material, and carrying out nitration reaction to obtain 2, 3, 4-trichloronitrobenzene; (2) the 2, 3, 4-trichloronitrobenzene is subjected to an ammonolysis reaction, and 2, 3-dichloro-6-nitroaniline is obtained; (3) carrying out diazotization reaction on the 2, 3-dichloro-6-nitroaniline, fluorine-containing inorganic acid and sodium nitrite in an organic solvent to generate diazonium salt, and then heating and decomposing to obtain 2-fluoro-3, 4-dichloronitrobenzene; and (4) reducing the 2-fluoro-3, 4-dichloronitrobenzene, so as to obtain the 3, 4-dichloro-2-fluoroaniline. According to the method, 1, 2, 3-trichlorobenzene serves as a raw material, and 3, 4-dichloro-2-fluoroaniline is obtained through the processes of nitration, ammonolysis, diazotization, decomposition, reduction and the like; the method provides a synthetic route of 3, 4-dichloro-2-fluoroaniline, and has the characteristics of simple process, easily controlled process, high product yield, high purity, low production cost and the like.