1429757-65-2

Usage

Uses

Used in Pharmaceutical Industry:
4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-ol is used as a potential pharmaceutical agent for its possible reactivity and interaction with biological systems. The presence of multiple heteroatoms and the quinazoline core may contribute to its activity against specific targets, such as enzymes or receptors, making it a candidate for drug development.
Used in Chemical Research:
In the field of chemical research, 4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-ol serves as a subject for studying the effects of its unique structural elements on chemical properties and reactivity. This can lead to a better understanding of how such compounds can be synthesized and potentially optimized for various applications.
Used in Material Science:
4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-ol may be utilized in material science applications, where its structural features could influence the properties of new materials. 4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-ol's potential for hydrogen bonding and its polarity could be harnessed in the design of novel materials with specific characteristics, such as improved stability or enhanced interaction with other molecules.

Upstream product

• 574745-97-4 4-chloro-6-hydroxy-7-methoxyquinazoline 
• 886762-39-6 3,4-dichloro-2-fluorobenzeneamine 
• 230955-75-6 6-acetoxy-4-chloro-7-methoxyquinazoline 
• 1429757-64-1 4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate 
• 179688-53-0 6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one 

Downstream Products

• 1092364-38-9 1-(4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-one 
• 1429757-68-5 1-[4-[4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy]-piperidin-1-yl]prop-2-en-1-one hydrochloride 

Relevant academic research and scientific papers

Compound used as kinase inhibitor, and application thereof

The invention relates to a compound used as a kinase inhibitor, and application thereof. The structure of the compound is shown as a formula I in the specification. The compound used as the kinase inhibitor provided by the invention has good inhibitory activity on EGFR and Her2 exon 20 insertion mutation, and has great potential to be developed into drugs for treating related diseases.

Inhibitor containing fused ring derivative as well as preparation method and application thereof

The invention relates to an inhibitor containing fused ring derivative as well as a preparation method and application thereof. Particularly, the invention relates to a compound as shown in a generalformula (I), a preparation method thereof, a pharmaceuti

Compound with nitrogen heterocyclic ring structure, and preparation method and application thereof

The invention discloses a compound with a nitrogen heterocyclic ring structure, and a preparation method and application thereof. The compound has an obvious inhibiting effect on an epidermal growth factor receptor (EGFR) inhibitor, can be used as an EGFR inhibitor for preparing medicines used for treating EGFR-mediated diseases including but not limited to malignant tumors and the like, and has wide application prospects.

Synthesis and evaluation of some novel 6-substituted quinazoline derivatives as antitumor agents

Summry: A series of novel 6-substituted quinazoline derivatives were synthesised as epidermal growth factor receptor(EGFR) and Human epidermal growth factor receptor 2 (HER2)inhibitors in our lab. The novel compounds were measured for their dual enzyme inhibition as well as their cytotoxic activity on MCF7 cell line. The results revealed that all the compounds showed inhibition of both enzymes. Compound 5c showed the best inhibitory activity against both enzymes and IC50 of its was 2.6 nM against EGFR kinases and 4.3 nM against HER2 kinases, respectively. Most of the measured compounds showed to antitumor activity on MCF7.

Substituted aminoquinazoline compounds and pharmaceutical compositions and uses thereof (by machine translation)

The amino quinazoline compound is a compound shown as a formula (I), or a pharmaceutically acceptable salt, a prodrug, a hydrate or a solvent compound, a crystal form, a stereoisomer or an isotopic variant. The compounds and compositions of the present invention may be used to treat and/or prevent ErbbB family tyrosine kinase mediated diseases. (by machine translation)

METHOD FOR PREPARING 1-(4-(4-(3,4-DICHLORO-2-FLUOROPHENYLAMINO)-7-METHOXYQUINAZOLIN-6-YLOXY)PIPERIDIN-1-YL)PROP-2-EN-1-ONE

The present invention relates to a method for manufacturing a targeted 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one in a much simple way compared to an existing method by conducting a reaction of a compound of chemical formula 2 and a compound of chemical formula 3, among polar aprotic solvents in the presence of a base.COPYRIGHT KIPO 2019

METHOD FOR PREPARING 1-(4-(4-(3,4-DICHLORO-2-FLUOROPHENYLAMINO)-7-METHOXYQUINAZOLIN-6-YLOXY)PIPERIDIN-1-YL)PROP-2-EN-1-ONE

The present invention relates to a novel method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one in a simpler process as compared with conventional methods by allowing 4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-ol to react with an N-acyl piperidine derivative in an inert polar protic solvent in the presence of a base.

METHOD FOR PREPARING 1-(4-(4-(3,4-DICHLORO-2-FLUOROPHENYLAMINO)-7-METHOXYQUINAZOLIN-6-YLOXY) PIPERIDIN-1-YL)-PROP-2-EN-1-ONE HYDROCHLORIDE AND INTERMEDIATES USED THEREIN

The present invention relates to an improved method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-one hydrochloride, which selectively and effectively inhibits the growth of cancer cells i