88683-45-8

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-[(4-methoxyphenyl)thio]-
• CAS NO: 88683-45-8
• Molecular Formula: C15H11NO3S
• Molecular Weight: 285.323
• Mol File: 88683-45-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-[(4-methoxyphenyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-[(4-methoxyphenyl)thio]-(88683-45-8)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-[(4-methoxyphenyl)thio]-(88683-45-8)

Safety Data

• Hazardous Substances Data: 88683-45-8(Hazardous Substances Data)

Usage

Derivative of isoindole

A heterocyclic compound that is modified from the parent compound isoindole, which is a 5-membered ring with one carbon atom replaced by nitrogen.

Methoxyphenylthio group

A functional group present in the compound, consisting of a sulfur atom bonded to a phenyl ring with a methoxy (CH3O) substituent.

Use in organic synthesis

The compound serves as an intermediate or building block in the synthesis of more complex organic molecules.

Application in medicinal chemistry

The compound may have potential applications in the development of pharmaceuticals, due to its unique structure and properties.

Interest to researchers

Scientists in the fields of organic synthesis and medicinal chemistry are interested in studying the properties and potential applications of this compound.

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 54974-07-1 phthalimidesulfenyl chloride 
• 136918-14-4 phthalimide 
• 1153-43-1 4,4'-dimethoxyphenyl thiosulfonate 

Downstream Products

• 1128077-16-6 C₂₁H₂₁NO₃S 
• 1128077-17-7 C₁₆H₁₉NO₃S 
• 1128077-19-9 2-(4-Methoxyphenylthio)pyrrole 
• 1128077-18-8 C₁₅H₁₉NOS 
• 99234-85-2 S-(4-methoxyphenyl)thiodiphenylphosphorus oxide 
• 1190852-22-2 (4-methoxyphenyl)(2-(trifluoromethyl)phenyl)sulfane 
• 25935-98-2 2,3-diphenyl-6-methoxybenzo[b]thiophene 

Relevant articles and documents

A Unified Strategy for Arylsulfur(VI) Fluorides from Aryl Halides: Access to Ar-SOF3 Compounds

A convenient protocol to selectively access various arylsulfur(VI) fluorides from commercially available aryl halides in a divergent fashion is presented. Firstly, a novel sulfenylation reaction with the electrophilic N-(chlorothio)phthalimide (Cl-S-Phth) and arylzinc reagents afforded the corresponding Ar-S-Phth compounds. Subsequently, the S(II) atom was selectively oxidized to distinct fluorinated sulfur(VI) compounds under mild conditions. Slight modifications on the oxidation protocol permit the chemoselective installation of 1, 3, or 4 fluorine atoms at the S(VI) center, affording the corresponding Ar-SO2F, Ar-SOF3, and Ar-SF4Cl. Of notice, this strategy enables the effective introduction of the rare and underexplored -SOF3 moiety into various (hetero)aryl groups. Reactivity studies demonstrate that such elusive Ar-SOF3 can be utilized as a linchpin for the synthesis of highly coveted aryl sulfonimidoyl fluorides (Ar-SO(NR)F).