88683-57-2Relevant academic research and scientific papers
Nucleoside phosphorothioate derivatives, synthesis and use thereof
-
, (2008/06/13)
Inter alia, a process for the production of a nucleoside phosphorothioate derivative corresponding to the following general formula (I): STR1 characterized in that it comprises reacting a salt of a nucleoside H-phosphonate corresponding to the following g
Preparation of 2-(2-cyanoethyl)sulfanyl-1H-isoindole-1,3-(2H)-dione and related sulfur-transfer agents
Klose, Jana,Reese, Colin B.,Song, Quanlai
, p. 14411 - 14416 (2007/10/03)
The title compound 3 and 4-[(2-cyanoethyl)sulfanyl]morpholine-3,5-dione 12 are both conveniently prepared in good yield from 2-cyanoethyl disulfide, which itself is readily prepared in one step from S-(2-cyanoethyl)isothiouronium chloride 4. In the same way, dimethyl and diphenyl disulfides are converted, into 2-methylsulfanyl- and 2-phenylsulfanyl-1H-isoindole-1,3-(2H)-diones 8a and 8b, respectively, also in good yields.
Synthesis of S-alkyl esters of protected 2'-deoribonucleoside 3'-phosphorothoates. Building blocks for the large-scale synthesis of phosphorothioate analogues of oligodeoxyribonucleotides by the phosphotriester approach in solution
Liu, Xiaohai,Reese, Colin B.
, p. 1685 - 1694 (2007/10/02)
Triethylammonium salts of 5'-O-(9-phenylxanthen-9-yl)-2'-deoxyribonucleoside 3'-(H-phosphonates) 23, 33a, 33b and 33c, derived from thymidine, 6-N-pivaloyl-2'-deoxyadenosine, 4-N-benzoyl-2'-deoxycitidine and 2-N-phenylacetyl-2'-deoxyguanosine, react with
