1001-58-7

Usage

Uses

Used in Research and Development Applications:
3-Mercaptopropiononitrile is used as a chemical intermediate for the synthesis of various organic compounds, particularly in the fields of pharmaceuticals and materials science. Its unique structure and reactivity make it a valuable building block for the development of new molecules with potential applications in drug discovery and material synthesis.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-mercaptopropiononitrile is used as a key component in the synthesis of certain drugs. Its ability to form stable bonds with other molecules allows for the creation of new therapeutic agents with improved pharmacological properties, such as enhanced bioavailability and targeted delivery to specific tissues or organs.
Used in Materials Science:
3-Mercaptopropiononitrile is employed as a precursor in the development of novel materials with unique properties, such as improved mechanical strength, thermal stability, or electrical conductivity. Its versatility in forming covalent bonds with a wide range of other compounds makes it an essential component in the synthesis of advanced materials for various applications, including electronics, aerospace, and renewable energy technologies.

InChI:InChI=1/C3H5NS/c4-2-1-3-5/h5H,1,3H2

Upstream product

• 507-09-5 thioacetic acid 
• 107-13-1 acrylonitrile 
• 42841-31-6 3,3’-dithiobis(propionitrile) 
• 10349-38-9 p-methoxyphenylisonitrile 
• 2417-90-5 bromopropionitrile 
• 57536-15-9 2-cyanoethyl carbamimidothioate 
• 119174-33-3 S-3-acetylthiopropionitrile 
• 6634-40-8 S‐(2‐cyanoethyl)isothiouronium chloride 

Downstream Products

• 505-29-3 1,4-Dithiane 
• 111-97-7 3,3'-thiobis-propanenitrile 
• 42841-31-6 3,3’-dithiobis(propionitrile) 
• 149997-74-0 3-(4-nitrophenyldithio)propionitrile 
• 149997-68-2 5-(2-cyanoethyldithio)-2-nitrobenzoic acid 
• 129395-59-1 C₄₈H₅₈N₅O₈PSSi 
• 129395-58-0 C₅₀H₆₀N₇O₈PSSi 
• 127105-12-8 O-(5'-O-dimethoxytritylthymidin-3'-yl) S-(2-cyanoethyl) N,N-diethylthiophosphoramidite 
• 142409-74-3 5'-O-(4,4'-Dimethoxytrityl)-4--thiothymidine 
• 117054-77-0 2-(2-Cyano-ethylsulfanyl)-3-nitro-benzamide 
• 117054-74-7 2-(2-Cyano-ethylsulfanyl)-N-ethyl-3-nitro-benzamide 
• 117054-81-6 2-(2-Cyano-ethylsulfanyl)-N,N-diethyl-3-nitro-benzamide 
• 127088-88-4 O-(5'-O-dimethoxytritylthymidin-3'-yl) S-(2-cyanoethyl) N,N-dimethylthiophosphoramidite 
• 149997-73-9 4-(2-cyanoethyldithio)benzensulfonamide 

Relevant academic research and scientific papers

New, stronger nucleophiles for nucleic acid-templated chemistry: Synthesis and application in fluorescence detection of cellular RNA

Nucleic acid-templated chemistry is a promising strategy for imaging genetic sequences in living cells. Here we describe the synthesis of two new nucleophiles for use in templated nucleophilic displacements with DNA probes. The nucleophilic groups are pho

Osmium-Mediated Transformation of 4-Thiouridine to Cytidine as Key To Study RNA Dynamics by Sequencing

To understand the functional roles of RNA in the cell, it is essential to elucidate the dynamics of their production, processing and decay. A recent method for assessing mRNA dynamics is metabolic labeling with 4-thiouridine (4sU), followed by thio-select

Efficient Synthesis of One- and Two-Dimensional Multimetallic Gold–Bis(dithiolene) Complexes

Multimetallic complexes having π-conjugated dithiolate ligands have recently received attention because of their unique solid-state properties. Reported herein are efficient and versatile routes for the synthesis of structurally well-defined multimetallic gold–bis(dithiolene) complexes. A dichlorogold(III) complex having a benzene-1,2-dithiolate ligand was prepared as a key terminal unit. A one-dimensional dimetallic gold complex was synthesized in good yield by using benzene-1,2,4,5-tetrathiolate as a bridging ligand. Furthermore, by using benzenehexathiolate as a bridging ligand, this strategy was applied to the synthesis of a two-dimensional trimetallic complex with a starburst structure. The solid-state structures of the anionic complexes were unambiguously confirmed by X-ray diffraction analyses.

N8-Glycosylated 8-Azapurine and Methylated Purine Nucleobases: Synthesis and Study of Base Pairing Properties

In this report, we present the synthesis of N8-glycosylated 8-aza-2-methylhypoxanthine and 8-aza-6-thiohypoxanthine 2′-deoxynucleosides as well as methylated 2′-deoxynebularine derivatives. In vitro base pairing properties between each modified and canonical nucleobase were studied. As demonstrated by Tm, incorporation of the modified bases in DNA resulted, with few exceptions, in low stability of duplexes. Modified bases studied in this report are preferentially recognized by T (for N8-glycosylated 8-aza-2-methylhypoxanthine and methylated purines) and G (N8-glycosylated 8-aza-2-methylhypoxanthine). The base pair formed between N8-glycosylated 8-aza-6-thiohypoxanthine and N9-glycosylated 2-methyl-6-thiohypoxanthine (X2:X6) showed, to some extent, an orthogonal interaction. Based on Tm studies, the only potential self-pairing system is formed by the N8-glycosylated 8-aza-6-thiohypoxanthine nucleoside (X2) but only in the absence of canonical G and T. This study indicated that the canonical thymine base is the preferential base partner of methylated purine bases.

Preparation of 2-(2-cyanoethyl)sulfanyl-1H-isoindole-1,3-(2H)-dione and related sulfur-transfer agents

The title compound 3 and 4-[(2-cyanoethyl)sulfanyl]morpholine-3,5-dione 12 are both conveniently prepared in good yield from 2-cyanoethyl disulfide, which itself is readily prepared in one step from S-(2-cyanoethyl)isothiouronium chloride 4. In the same way, dimethyl and diphenyl disulfides are converted, into 2-methylsulfanyl- and 2-phenylsulfanyl-1H-isoindole-1,3-(2H)-diones 8a and 8b, respectively, also in good yields.

A general and mild synthesis of thioesters and thiols from halides

The conversion of a wide variety of halides to thioesters by reaction with potassium thiocetate under mild conditions is described, and the generality of the method is demonstrated.

Thioguanosine Conversion Enables mRNA-Lifetime Evaluation by RNA Sequencing Using Double Metabolic Labeling (TUC-seq DUAL)

Temporal information about cellular RNA populations is essential to understand the functional roles of RNA. We have developed the hydrazine/NH4Cl/OsO4-based conversion of 6-thioguanosine (6sG) into A′, where A′ constitutes a 6-hydraz

Novel low-cost green 3 - production process for CO-production of sodium thiomalononitrile by sulfydryl propionitrile (by machine translation)

The invention discloses a novel low-cost green 3 - production process S2 for CO-producing sodium thiomalononitrile by using sodium thiopropionitrile, and the S1 specific steps are as follows 30 - 35 °C S2 S1 S3 8 °C S4 S3 S5 S2 S6 S4 S4 S7 S6 S5. The reac

METHOD FOR PRODUCING 3-MERCAPTOPROPIONIC ACID, AND METHODS USING SAME FOR PRODUCING CARBOXYLIC ACID ESTER COMPOUND HAVING MERCAPTO GROUP AND THIOURETHANE-BASED OPTICAL MATERIAL

A method for producing 3-mercaptopropionic acid and methods using same for producing a carbonic acid ester compound having a mercapto group and a thiourethane-based optical material. The present invention improves a process during the production of 3-mercaptopropionic acid, significantly increases yield, and reduces the temperature and time during vacuum distillation, thereby preventing the destruction of a product and significantly increasing productivity. The present invention allows high-purity 3-mercaptopropionic acid having an excellent color to be finally yielded; accordingly, by using same, a high-purity carbonic acid ester compound having an excellent color and a mercapto group can be inexpensively obtained. A thiourethane-based polymeric composition and a thiourethane-based optical material obtained by polymerizing same can likewise be inexpensively obtained by using said carbonic acid ester compound. Such carbonic acid ester compound can be used for the production of inexpensive thiourethane optical lenses; consequently, inexpensive optical lenses having an excellent color can be obtained.

A method for preparing thiol compounds

The invention provides a preparation method of a thiol compound. According to the preparation method, gas-liquid reaction is carried out on sulfuretted hydrogen and an organic compound containing carbon-carbon double bonds in a solid base catalyst and a reaction solvent through Michael addition under the conditions that the temperature is 20-80 DEG C and the pressure is 0.10-0.12MPa, so as to prepare the thiol compound. The preparation method is mild in reaction condition; the adopted solid base catalyst is strong in alkalinity; the alkaline catalysis position has relatively strong steric hindrance, and the applicability is wide; the solid base catalyst is easy to filter and recover, and can be repeatedly used after being activated; the reaction conversion rate and the selectivity are high; the side reaction is reduced; and the atomic economic utilization rate of the reaction is high.