88695-48-1

Basic information

• Product Name: 2-{3-[(4-methoxyphenyl)(methyl)amino]-2-oxopropyl}-1H-isoindole-1,3(2H)-dione
• CAS NO: 88695-48-1
• Molecular Formula: C₁₉H₁₈N₂O₄
• Molecular Weight: 338.3572
• Mol File: 88695-48-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 522.4°C at 760 mmHg
• Flash Point: 269.7°C
• Density: 1.3g/cm³
• Vapor Pressure: 5.21E-11mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: 2-{3-[(4-methoxyphenyl)(methyl)amino]-2-oxopropyl}-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{3-[(4-methoxyphenyl)(methyl)amino]-2-oxopropyl}-1H-isoindole-1,3(2H)-dione(88695-48-1)
• EPA Substance Registry System: 2-{3-[(4-methoxyphenyl)(methyl)amino]-2-oxopropyl}-1H-isoindole-1,3(2H)-dione(88695-48-1)

Safety Data

• Hazardous Substances Data: 88695-48-1(Hazardous Substances Data)

Usage

Structure

Isoindole core with 2-oxopropyl and 4-methoxyphenyl(methyl)amino side chains

Type

Synthetic organic compound

Application

Medicinal chemistry and pharmaceutical research

Potential

Pharmacological activities, drug discovery and development

Interest

Chemical structure and properties for therapeutic agent development

Upstream product

• 6284-26-0 2-(3-bromo-2-oxopropyl)-1H-isoindole-1,3 (2H)-dione 
• 5961-59-1 N-methyl-N-(4-methoxyphenyl)amine 

Relevant articles and documents

New Anticancer Agents: Synthesis of 1,2-Dihydropyridopyrizines (1-Deaza-7,8-dihydropteridines)

Reaction of α-aminoacetophenone oximes (2) with ethyl 6-amino-4-chloro-5-nitropyridine-2-carbamate (1) gave ethyl 6-amino-5-nitro-4-pyridine-2-carbamate oximes (3), which were hydrolyzed under acidic conditions to give the corresponding ketones (4).Related pyridines substituted with keto side chain were prepared from 1 and 1,3-diaminopropanone oximes and by oxidation of the side-chain hydroxy group of ethyl 6-amino-4-amino>-5-nitropyridine-7-carbamates (6).Catalytic hydrogenation of the nitro group of 4 over Raney nickel in a large volume of ethanol gave the 1-deaza-7,8-dihydropteridines (7).Several of the oximes 3 were successfully hydrogenated to give 7 directly.The resulting 1-deaza-7,8-dihydropteridines showed potent cytotoxicity against cultured L1210 cells and significant anticancer activity against lymphocytic leukemia P-388 in mice.THese biological activities are attributed to the accumulation of cells at mitosis.