88701-60-4Relevant academic research and scientific papers
Synthesis of 5H-Furobenzopyranopyridin-5-ones and 8H-Pyranobenzofuropyridin-8-ones
Moron, Jacqueline,Nguyen, Chi Hung,Bisagni, Emile
, p. 225 - 229 (2007/10/02)
5H-Furobenzopyranopyridin-5-ones(pyridopsoralens) (3) have been obtained by the von Pechmann reaction starting from 6-hydroxy-2,3-dihydrobenzofuran acetates plus 1-benzyl-3-ethoxycarbonylpiperidin-4-one and subsequent dehydrogenation.The synthesis of their 8H-pyranobenzofuropyridin-8-one isomers (14) and (17) was achived by two ways using: (i) ring closure of 4-formyl-3-hydroxy-2-methylbenzofuropyridine, and (ii) cyclisation of piperidinone O-(4,7-dimethylcoumarin-7-yl)oxime derivatives and aromatization.
