88701-86-4

Upstream product

• 100-52-7 benzaldehyde 
• 4827-64-9 4-methylbenzo[e][1,2,3]oxathiazine 2,2-dioxide 
• 51299-06-0 4-oxo-3,4-dihydro-1,2,3-benzoxathiazine 2,2-dioxide 
• 118-93-4 o-hydroxyacetophenone 
• 1214-47-7 1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one 
• 888-12-0 (E)-2'-hydroxy-chalcone 

Downstream Products

• 119867-67-3 9b-((E)-Styryl)-1,9b-dihydro-5-oxa-4-thia-2,3,3a-triaza-cyclopenta[a]naphthalene 4,4-dioxide 

Relevant academic research and scientific papers

NH4OAc-Promoted Domino Route to Hydroxyarylated Unsymmetrical Pyridines under Neat Conditions

A new metal-, oxidant-, and solvent-free ecofriendly domino method has been established for modular synthesis of a diverse range of medicinally promising hydroxyarylated unsymmetrical pyridines in good to high chemical yields with an excellent regioselect

Palladium-catalyzed stereoselective (3 + 2) cycloaddition of vinylethylene carbonates with cyclicN-sulfonyl ketimines

A diastereoselective (3 + 2) cycloaddition ofN-sulfonyl ketimines with vinylethylene carbonates (VECs) in the presence of Pd2dba3·CHCl3and PPh3has been developed. The reaction of various substituted VECs and diverse cyclicN-sulfonyl ketimines proceeded smoothly under mild conditions, giving highly functionalized oxazolidine frameworks in good to excellent yields with moderate to good diastereoselectivities. With the use of spiroketal-based diphosphine SKP as a chiral ligand, an asymmetric version of the current (3 + 2) cycloaddition was achieved, and chiral products were obtained in >99% ee in most cases.

The Construction of 3-Methyl-4-arylpiperidines via a trans- Perhydroindolic Acid-Catalyzed Asymmetric Aza-Diels-Alder Reaction

An efficient trans-perhydroindolic acid-catalyzed asymmetric aza-Diels-Alder reaction of cyclic 1-azadienes and propanal was developed for the synthesis of chiral 3-methyl-4-aryldehydropiperidine derivatives (up to 98% yield and 99% ee). Such scaffolds are often found in bioactive compounds and medicines. A gram-scale reaction was carried out with a low catalyst loading to give the desired product in high yield and with excellent enantioselectivity. The resulting dehydropiperidine derivatives can be further transformed to chiral 3-methyl-4-aryl-substituted piperidines with high efficiency.

Highly functionalized pyridines synthesis from N-sulfonyl ketimines and alkynes using the N-S bond as an internal oxidant

The N-S bond-based internal oxidant offers a distinct approach for the synthesis of highly functionalized pyridines. A novel Rh(III)-catalyzed one-pot process undergoes an efficient C-C/C-N bond formation along with desulfonylation under very mild conditions. The method is quite simple, general, and efficient.

Reaction of 4-Styryl-1,2,3-benzoxathiazine 2,2-Dioxides with Diazomethane: Synthesis of a Novel Heterocyclic System

A new class of heterocyclic system, 3a-f, has been synthesized by reacting diazomethane with 4-styryl-1,2,3-benzoxathiazine 2,2-dioxides 1a-f.Diazomethane adds to the =C=S group of these compounds.