88703-86-0Relevant academic research and scientific papers
Synthesis, Surface Properties, and Antibacterial Activity of Novel Ester-Containing Cationic Silicone Surfactants and Their Utilization as Fabric-Finishing Agents
Wei, Yuan,Zheng, Cheng,Zhang, Zhenqiang,Zeng, Zhaowen,Mao, Taoyan,Long, Shikang,Ling, Hui
, p. 285 - 299 (2018/10/24)
In this study, a series of cationic silicone surfactants SiQCnCl containing ester groups and double long-chain alkyls (n = 9, 11, 13, 15, and 17) were synthesized by microwave irradiation and characterized using infrared Fourier transform (FTIR), 1H nuclear magnetic resonance (1H NMR), and thermogravimetric analysis (TGA). Surface activity and adsorption of these surfactants were investigated by measuring the equilibrium surface tension. The critical micelle concentration (CMC) decreased with increasing alkyl length of SiQCnCl at 25 °C and so did the corresponding surface tension at the CMC (γCMC). The aggregation behavior in aqueous solutions was also investigated systemically through transmission electron microscopy (TEM) and dynamic light scattering (DLS). Spherical or ellipsoidal-like aggregates with diameters ranging from 300 to 900 nm were observed. It is also shown that the cationic silicone surfactants exhibit certain antibacterial properties against Staphylococcus aureus but slightly poor to Escherichia coli. The morphological structure of SiQC15Cl-treated cotton fabrics was observed using scanning electron microscopy (SEM), which showed that the surface became neat and smooth. What is more, the finished cotton fabrics maintained some antibacterial properties with improved softness, which may provide a more comfortable and healthy lifestyle. This work may also be helpful to the design and application of functional cationic silicone surfactants.
Preparation and characterization of phase-segregated vesicles of photopolymerizable diacetylene mixed with nonpolymerizable amphiphiles
Matsumoto, Jin,Yoneda, Koshiro,Tasaka, Jun,Shiragami, Tsutomu,Yasuda, Masahide
experimental part, p. 1551 - 1557 (2011/03/16)
A mixture of sodium 1,2-di(hexadecyloxycarbonyl)ethanesulfonate (2C16S) with photopolymerizable 1,2-di(10,12- tricosadiynoyl)-sn-glycerol 3-phosphocholine (DTPC) in a 2:100 ratio was treated by modified thin-film hydration to give an aggregate which became polymerized giant vesicles (GVs) under irradiation at 254 nm. The autofluorescence of the GVs was analyzed with a confocal laser scanning microscope at the cross section, revealing a 3.8-μm diameter ring shape and the presence of a dark part of ca. 1 μm in the ring. When octadecylrhodamine B (RhB) as an amphiphilic fluorescence probe was added to the GV, the fluorescence of RhB was emitted from the whole ring. Therefore, phase segregation of 2C16S from DTPC was confirmed. Similarly, mixed vesicles of N,N-di(2-hexadecanoyloxyethyl)dimethylammonium iodide with DTPC were found to be 3.7-μm diameter phase-segregated vesicles with a dark portion of ca. 1 μm on the ring in the cross sectional image. On the other hand, DTPC vesicles mixed with 1,2-di(dodecyloxycarbonyl)ethanesulfonate, N,N-di(2- dodecanoyloxyethyl)dimethylammonium iodide, and N,N-di(2-tetradecanoyloxyethyl) dimethylammonium iodide formed sphere structures filling the inside of the vesicles. The segregation mechanism was explained by the difference in the main phase transition temperature of each amphiphile.
Novel series of non-glycerol-based cationic transfection lipids for use in liposomal gene delivery
Banerjee, Rajkumar,Prasanta Kumar, Das,Srilakshmi, Gollapudi Venkata,Chaudhuri, Arabinda,Nalam Madhusudhana, Rao
, p. 4292 - 4299 (2007/10/03)
A novel series of nontoxic and non-glycerol-based simple monocationic transfection lipids containing one or two hydroxyethyl groups directly linked to the positively charged nitrogen atom were synthesized. The in vitro transfection efficiencies of these new liposomal gene delivery reagents were better than that of lipofectamine, a widely used transfection agent in cationic lipid-mediated gene transfer. The most efficient transfection formulation was observed to be a 1:1:0.3 mol ratio of DHDEAB (N,N-di-n- hexadecyl-N,N-dihydroxyethylammonium bromide): cholesterol:HDEAB (N-n- hexadecyl-N,N-dihydroxyethylammonium bromide) using a DHDEAB-to-DNA charge ratio (+/-) of 0.3:1. Observation of good transfection at charge ratios lower than i suggests that the amphiphile-DNA complex may have net negative charge. Our results reemphasize the important point that in cationic lipid-mediated gene delivery, the overall charge of the lipid-DNA complex need not always be positive. In addition, our transfection results also imply that favorable hydrogen-bonding interactions between the lipid headgroups and the cell surface of biological membranes may have some role for improving the transfection efficiency in cationic lipid-mediated gene delivery.
