887202-20-2Relevant academic research and scientific papers
Synthesis of 5,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidin-4(3H)-ones and their N-alkylation's under phase transfer conditions
Dave, Chaitanya G.,Patel, Killol J.
, p. 943 - 947 (2014/08/05)
5,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidin-4(3H)-ones 2 were synthesized by the cyclocondensation of 1,4-disubstituted 2-amino-3-cyanopyrrole 1 with formic acid. When comparative study of N versus O alkylation of ambident 5,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidin-4(3H)-ones 2 was carried out under liquid-liquid PTC, solid-liquid PTC, and solid-liquid solvent free conditions using various alkylating agents 3, the N-alkylated product 4 were obtained selectively and exclusively.
