887254-64-0Relevant academic research and scientific papers
Electron-donating and rigid p-stereogenic bisphospholane ligands for highly enantioselective rhodium-catalyzed asymmetric hydrogenations
Zhang, Xiaowei,Huang, Kexuan,Hou, Guohua,Cao, Bonan,Zhang, Xumu
, p. 6421 - 6424 (2010)
More electron donating, more rigid: A new highly electron-donating P-stereogenic bisphospholane ligand (ZhangPhos) was synthesized in a practical and highly enantioselective manner from a commercially available chiral source. Better or comparable enantioselectivities and reactivities than TangPhos were achieved in rhodium-catalyzed hydrogenation of various functionalized olefins (see scheme; nbd=3,5-norbornadiene). Copyright
Axial 4,4′,6,6′-tetrakis-trifluoromethyl-biphenyl-2, 2′diamine (TF-BIPHAM): Resolution and applications in asymmetric hydrogenation
Wang, Chun-Jiang,Gao, Feng,Liang, Gang
supporting information; experimental part, p. 4711 - 4714 (2009/05/31)
(Equation Presented) The racemic TF-BIPHAM was resolved for the first time, and the effectiveness of the resolved diamine was demonstrated by highly enantioselective hydrogenation of α-aryl enamides and α-dehydroamino acid esters using readily accessible
Imidazo-fused oxazolo[4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
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Page/Page column 28, (2010/11/30)
The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
