887279-05-2Relevant academic research and scientific papers
Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors
Lacombe, Patrick,Deschenes, Denis,Dube, Daniel,Dube, Laurence,Gallant, Michel,Macdonald, Dwight,Mastracchio, Antony,Perrier, Helene,Charleson, Stella,Huang, Zheng,Laliberte, France,Liu, Susana,Mancini, Joseph A.,Masson, Paul,Salem, Myriam,Styhler, Angela,Girard, Yves
, p. 2608 - 2612 (2007/10/03)
Potent inhibitors of the human PDE IV enzyme are described. Substituted 8-arylquinoline analogs bearing nitrogen-linked side chain were identified as potent inhibitors based on the SAR described herein. The pharmacokinetic profile of the best analog and t
