88728-90-9

Upstream product

• 88670-17-1 5-isopropyl-2-methyl-7a-phenylhexyhydropyrrolizin-3-one 
• 100-39-0 benzyl bromide 
• 2051-95-8 succinylbenzene 
• 620-05-3 iodomethylbenzene 
• 2026-48-4 (S)-valinol 
• 74-88-4 methyl iodide 
• 88670-18-2 (3S,6S,7aS)-6-Benzyl-3-isopropyl-7a-phenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one 
• 88670-16-0 (3S,7aS)-3-isopropyl-7a-phenyl-5-oxo-2,3,5,6,7,7a-hexahydropyrrolo<2,1-b>oxazole 

Downstream Products

• 88670-32-0 (R)-2-Methyl-4-phenyl-1,2-dihydro-naphthalene-2-carboxylic acid 
• 88670-33-1 (S)-2-methyl-2-carbomethoxy-4-phenyl-1,2-dihydronaphthalene 
• 88670-26-2 (R)-n-butyl 2-methyl-2-benzyl-3-benzoylpropionate 

Relevant academic research and scientific papers

Synthesis of chiral 4,4-disubstituted-dihydropyridazines

In this paper, a novel general route to the stereospecific synthesis of chiral dihydropyridazines relying on the stereospecific formation of 1,4-diones is presented. The chirality is provided through the application of bicyclic lactams to the synthesis of

The Asymmetric Synthesis of 2,2-Dialkyl Carboxylic Esters and 2,2-Disubstituted Dihydronaphthalenes

The bicyclic lactams derived from (S)-valinol and 3-benzoylpropionic acid or levulinic acid are useful chiral precursors to the title compounds.Metalation of bicyclic lactams 1 and 4 and alkylation followed by acidic hydrolysis leads to racemic 2-alkyl carboxylic acids.However, sequential metalation-alkylation to 2,2-dialkyl bicyclic lactams 2 and 5 furnishes these systems with good diastereoselectivity.Treatment of 5 with triflic acid causes a facile rearrangement to the oxalines 7 and hydrolysis leads to the carboxylic esters.Under certain conditions, hydrolysis leads directly to naphthalenes 11.