88733-56-6Relevant articles and documents
Preparation method of sulfasalazine impurity D
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, (2020/07/24)
The invention discloses a preparation method of a sulfasalazine impurity D, belongs to the field of drug impurity synthesis, and provides the preparation method of the sulfasalazine impurity D, whichis reasonable in process design, strong in operability,
Site-selective arene C-H amination via photoredox catalysis
Romero, Nathan A.,Margrey, Kaila A.,Tay, Nicholas E.,Nicewicz, David A.
, p. 1326 - 1330 (2015/10/12)
Over the past several decades, organometallic cross-coupling chemistry has developed into one of the most reliable approaches to assemble complex aromatic compounds from preoxidized starting materials. More recently, transition metal-catalyzed carbon-hydrogen activation has circumvented the need for preoxidized starting materials, but this approach is limited by a lack of practical amination protocols. Here, we present a blueprint for aromatic carbon-hydrogen functionalization via photoredox catalysis and describe the utility of this strategy for arene amination. An organic photoredox-based catalyst system, consisting of an acridinium photooxidant and a nitroxyl radical, promotes site-selective amination of a variety of simple and complex aromatics with heteroaromatic azoles of interest in pharmaceutical research. We also describe the atom-economical use of ammonia to form anilines, without the need for prefunctionalization of the aromatic component.
Identification of pharmacophore model, synthesis and biological evaluation of N-phenyl-1-arylamide and N-phenylbenzenesulfonamide derivatives as BACE 1 inhibitors
Huang, Wenhai,Yu, Haiping,Sheng, Rong,Li, Jia,Hu, Yongzhou
experimental part, p. 10190 - 10197 (2009/04/07)
The pharmacophore model of arylpiperazine amide derivatives was built using Discovery Studio 2.0 software package and the best pharmacophore model (Hypo 1) was validated by Enrichment and ROC method (EF at 2%, 5% and 10% are 30.6, 12.2 and 7.7; AUC of the
