88735-83-5Relevant academic research and scientific papers
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: A first round of lead optimization
La Pietra, Valeria,Marinelli, Luciana,Cosconati, Sandro,Di Leva, Francesco Saverio,Nuti, Elisa,Santamaria, Salvatore,Pugliesi, Isabella,Morelli, Matteo,Casalini, Francesca,Rossello, Armando,La Motta, Concettina,Taliani, Sabrina,Visse, Robert,Nagase, Hideaki,Da Settimo, Federico,Novellino, Ettore
experimental part, p. 143 - 152 (2012/03/09)
Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly patients, and is characterized by progressive loss of articular cartilage. Among the various matrix metalloproteinases (MMPs), MMP-13 is specifically expresse
Efficient, stereoselective approach to the synthesis of 3-(1-Phenyl-2-(Z-styrylsulfonyl)-1H-imidazol-4-yl)-2H-chromen-2-ones
Guravaiah, Nalajam,Rao, Vedula Rajeswar
, p. 1167 - 1174 (2011/05/06)
Reaction of phenyl acetylene with 3-(1-aryl-2-mercapto-4-imidazolyl)-2H-1- benzopyran-2-ones (4) in the presence of sodium hydroxide in absolute ethanol led to the formation of 3-(1-phenyl-2-(Z-styrylthio)-1H-imidazol-4-yl)-2H- chromen-2-ones (6) in excel
Synthesis of 3-(1-aryl-2-mercapto-imidazolyl)-2H-1-benzopyran-2-one derivatives
Kumar, Ravi V.,Rao, V. Rajeswar
, p. 415 - 418 (2007/10/03)
Reaction of 3-(2-bromoacetyl) coumarins with various substituted aromatic primary amines resulted in the formation of 3-(2-anilino acetyl) coumarins 1 which on subsequent reaction with potassium thiocyanate furnishes corresponding 3-(1-aryl-2-mercapto-imi
α,β-UNSATURATED KETONES AND ANILIDES OF THE COUMARIN SERIES IN THE SYNTHESIS OF ISOXAZOLE, IMIDAZOLE, AND PYRAZOLE DERIVATIVES
Skripskaya, O. V.,Yagodinets, P. I.,Chernyuk, I. N.
, p. 1625 - 1627 (2007/10/03)
Coumarin-containing unsaturated ketones react with bromine to give dibromides, which form derivatives of isoxazoles and pyrazoles via reaction with hydroxylamine hydrochloride or phenylhydrazine.A method for preparing coumarin-containing imidazoles from the corresponding anilides was elaborated.
3-α-Bromacetyl-coumarines as Synthones for Heterocyclic Substituted Coumarines
Czerney, P.,Hartmann, H.
, p. 551 - 560 (2007/10/02)
3-α-Bromacetyl-coumarines 2 react easily and in high yields with thiourea and thioamide derivatives 3 and 5, resp., to 4-coumar-3'-yl-thiazoles 4 and 6, resp., as well as with N,N-disubstituted thioamides 11 and N,N,N',N'-tetraalkylthiourea 12 to 5-coumar-3'-yl-oxathioliumsalts 13 and 14, respectively.In a two-step reaction 2 can be transformed by reaction with aniline 17 to 4-coumar-3'-yl-imidazoles 21 and 5-coumar-3'-yl-oxazoliumsalts 22, resp., via aminoketone intermediates 18.
