88735-83-5Relevant articles and documents
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: A first round of lead optimization
La Pietra, Valeria,Marinelli, Luciana,Cosconati, Sandro,Di Leva, Francesco Saverio,Nuti, Elisa,Santamaria, Salvatore,Pugliesi, Isabella,Morelli, Matteo,Casalini, Francesca,Rossello, Armando,La Motta, Concettina,Taliani, Sabrina,Visse, Robert,Nagase, Hideaki,Da Settimo, Federico,Novellino, Ettore
experimental part, p. 143 - 152 (2012/03/09)
Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly patients, and is characterized by progressive loss of articular cartilage. Among the various matrix metalloproteinases (MMPs), MMP-13 is specifically expresse
Synthesis of 3-(1-aryl-2-mercapto-imidazolyl)-2H-1-benzopyran-2-one derivatives
Kumar, Ravi V.,Rao, V. Rajeswar
, p. 415 - 418 (2007/10/03)
Reaction of 3-(2-bromoacetyl) coumarins with various substituted aromatic primary amines resulted in the formation of 3-(2-anilino acetyl) coumarins 1 which on subsequent reaction with potassium thiocyanate furnishes corresponding 3-(1-aryl-2-mercapto-imi
3-α-Bromacetyl-coumarines as Synthones for Heterocyclic Substituted Coumarines
Czerney, P.,Hartmann, H.
, p. 551 - 560 (2007/10/02)
3-α-Bromacetyl-coumarines 2 react easily and in high yields with thiourea and thioamide derivatives 3 and 5, resp., to 4-coumar-3'-yl-thiazoles 4 and 6, resp., as well as with N,N-disubstituted thioamides 11 and N,N,N',N'-tetraalkylthiourea 12 to 5-coumar-3'-yl-oxathioliumsalts 13 and 14, respectively.In a two-step reaction 2 can be transformed by reaction with aniline 17 to 4-coumar-3'-yl-imidazoles 21 and 5-coumar-3'-yl-oxazoliumsalts 22, resp., via aminoketone intermediates 18.
