887375-49-7

Usage

Uses

Used in Pharmaceutical Industry:
(2R)-2-(Ethoxycarbonyl)-1,1,1-trifluoro-4-methylpent-4-en-2-ol is used as a building block for the synthesis of various pharmaceuticals. Its unique structure allows for the creation of complex organic compounds that can be used in the development of new drugs.
Used in Agrochemical Industry:
(2R)-2-(Ethoxycarbonyl)-1,1,1-trifluoro-4-methylpent-4-en-2-ol is used as a building block for the synthesis of agrochemicals. Its versatility in organic synthesis allows for the development of new compounds that can be used in agriculture to improve crop yield and protect against pests.
Used in Fine Chemicals Industry:
(2R)-2-(Ethoxycarbonyl)-1,1,1-trifluoro-4-methylpent-4-en-2-ol is used as a building block for the synthesis of fine chemicals. Its unique properties make it a valuable reagent in the production of specialty chemicals used in various industries.
It is important to handle (2R)-2-(Ethoxycarbonyl)-1,1,1-trifluoro-4-methylpent-4-en-2-ol with care and use proper safety precautions, as it can be toxic if ingested or inhaled.

Upstream product

• 13081-18-0 ethyl-3,3,3-trifluoropyruvate 
• 115-11-7 isobutene 

Relevant academic research and scientific papers

Preparation (R)-2 - hydroxy -2 - trifluoromethyl -4 - methyl -4 - pentenoic acid ethyl ester (by machine translation)

The present invention discloses a low-temperature control asymmetric catalytic preparation of high optical purity of the (R)- 2 - hydroxy - 2 - trifluoromethyl - 4 - methyl - 4 - pentenoic acid ethyl ester method, comprises the following steps: (1) measure the right amount of trifluoro pyruvate b the ester puts in the baking of the reaction tube; (2) the catalyst to prepare the catalyst solution, the amount of injection for taking certain amount and adding said step (1) in the reaction system, mixing; (3) condition and cooling; (4) isobutene solution is added to step (3) in the reaction system, the starting reaction; (5) after the reaction is finished, the step (4) of the reaction to produce the products of the after-treatment, distillation, to get the pure product. The invention of good stereoselectivity, ee value can be up to 97% - 98%; yield relatively high, can reach 90%, and in the absence of other generation of secondary reaction. (by machine translation)

Asymmetric carbonyl-ene reaction of trifluoropyruvate catalyzed by Pd(II)-SunPhos complex

An efficient asymmetric carbonyl-ene reaction of trifluoropyruvate catalyzed by chiral Pd(II)/(S)-SunPhos complex was developed. A series of optically active homoallylic alcohols containing a CF3 group were obtained with high yields and excellent ee under mild conditions. Particularly, the reaction of isobutylene and trifluoropyruvate gave the desired product (90% yield, 98% ee) with catalyst loading as low as 0.01 mol% in dichloroethane/toluene.

Chiral Pd-catalyzed trifluoropyruvate-ene reactions with steroidal side chains for late-stage fluoromethyl-functionalization: remarkably high agonist activities of ene products even in low VDR binding affinity

Abstract The highly enantioselective trifluoropyruvate-ene reactions of chiral steroid side chain olefins were achieved by dicationic palladium complexes as chiral Lewis acid catalysts to give steroidal ene-products in high diastereoselectivity. The ene p

METHOD FOR PRODUCING OPTICALLY ACTIVE FLUORINE-CONTAINING CARBONYL-ENE PRODUCT

An optically active, fluorine-containing carbonyl-ene product is produced by reacting a fluorine-containing α-ketoester with an alkene in the presence of a transition metal complex having an optically active ligand. There are Mode 1 of conducting this rea