(2R)-2-(Ethoxycarbonyl)-1,1,1-trifluoro-4-methylpent-4-en-2-ol

Base Information

• Chemical Name: (2R)-2-(Ethoxycarbonyl)-1,1,1-trifluoro-4-methylpent-4-en-2-ol
• CAS No.: 887375-49-7
• Molecular Formula: C₉H₁₃F₃O₃
• Molecular Weight: 226.196
• Hs Code.: 2918199090
• Mol file: 887375-49-7.mol

Synonyms:(2R)-2-(Ethoxycarbonyl)-1,1,1-trifluoro-4-methylpent-4-en-2-ol;Ethyl (2R)-2-hydroxy-4-methyl-2-(trifluoromethyl)pent-4-enoate

Chemical Property of (2R)-2-(Ethoxycarbonyl)-1,1,1-trifluoro-4-methylpent-4-en-2-ol

Chemical Property:

• PSA: 46.53000
• LogP: 1.80910

Purity/Quality:

97% ^*data from raw suppliers

Ethyl (2R)-2-hydroxy-4-methyl-2-(trifluoromethyl)pent-4-enoate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R)-2-(Ethoxycarbonyl)-1,1,1-trifluoro-4-methylpent-4-en-2-ol

There total 2 articles about (2R)-2-(Ethoxycarbonyl)-1,1,1-trifluoro-4-methylpent-4-en-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl-3,3,3-trifluoropyruvate (13081-18-0) + isobutene (115-11-7,15220-85-6) → (R)-ethyl 2-hydroxy-4-methyl-2-(trifluoro-me thyl)pent-4-enoate (887375-49-7)

Guidance literature:

ethyl-3,3,3-trifluoropyruvate; With silver hexafluoroantimonate; PdCl₂[(S)-SunPhos]; In 1,2-dimethoxyethane; 1,2-dichloro-ethane; at 25 ℃; for 0.5h; Schlenk technique; Inert atmosphere;

isobutene; In 1,2-dimethoxyethane; 1,2-dichloro-ethane; toluene; at -20 - -15 ℃; for 12h; enantioselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tet.2017.10.044

Reference yield:

ethyl-3,3,3-trifluoropyruvate (13081-18-0) + isobutene (115-11-7,15220-85-6) → (S)-ethyl 2-hydroxy-4-methyl-2-trifluoromethyl-4-pentenoate (887375-50-0) + (R)-ethyl 2-hydroxy-4-methyl-2-(trifluoro-me thyl)pent-4-enoate (887375-49-7)

Guidance literature:

(R)-BINAP-Pd⁽²⁺⁾(OH₂)2*2SbF₆^(1-); In dichloromethane; at -20 ℃; for 2h; Product distribution / selectivity; Inert atmosphere;

upstream raw materials:

ethyl-3,3,3-trifluoropyruvate

isobutene