887402-85-9Relevant academic research and scientific papers
Synthetic studies toward the immunosuppressant FR901483. Facile construction of the azatricyclic skeleton
Simila, Suvi T. M.,Reichelt, Andreas,Martin, Stephen F.
, p. 2933 - 2936 (2006)
A concise synthesis of the azatricyclic core structure of FR901483, a potent immunosuppressant, has been accomplished. The key elements of the approach involve a nucleophilic addition to an acyl iminium ion, a ring closing metathesis and a lactone-lactam
Toward the total synthesis of FR901483: Concise synthesis of the azatricyclic skeleton
Simila, Suvi T. M.,Martin, Stephen F.
, p. 5342 - 5349 (2008/02/08)
(Chemical Equation Presented) A concise synthesis of the azatricyclic core of FR901483 has been accomplished using a novel strategy that involves a nucleophilic addition to an N-acyl iminium ion, a ring-closing metathesis, a diastereoselective hydroborati
