887406-28-2Relevant academic research and scientific papers
Synthesis and antidiabetic evaluation of benzothiazole derivatives
Mariappan,Prabhat,Sutharson,Banerjee,Patangia,Nath
, p. 251 - 256 (2012/06/01)
A novel series of benzothiazole derivatives were synthesized and assayed in vivo to investigate their hypoglycemic activity by streptozotocin-induced diebetic model in rat. These derivatives showed considerable biological efficacy when compared to glibenclamide, a potent and well known antidiabetic agent as a reference drug. All the compounds were effective, amongst them 3d showed more prominent activity at 100 mg/kg p.o. The experimental results are statistically significant at p0.01 and p0.05 level.
Synthesis of benzothiazole derivatives having acetamido and carbothioamido pharmacophore as anticonvulsant agents
Amir, Mohd,Asif,Ali, Israr,Hassan, Mohd Zaheen
, p. 2661 - 2670 (2012/10/30)
A new series of N-(6-chlorobenzothiazol-2-yl)-2-substituted-acetamides (3a-h) and N-(6-chlorobenzothiazol-2-yl)-2-(substituted-benzylidene) hydrazinecarbothioamides (5a-h) were synthesized and characterized by IR, 1HNMR, mass and elemental analysis. In vivo anticonvulsant and acute toxicity screening of all the synthesized compounds showed morpholino (3f) and imidazolyl (3g) derivatives as promising anticonvulsant lead. Furthermore, In silico druglikeness parameters have also been investigated for filtering out the likelihood of poor drug absorption or brain penetration. 3D four-point pharmacophore measurements of compounds were also carried out to match these with established anticonvulsants agents. Springer Science+Business Media, LLC 2011.
