88754-96-5

Basic information

• Product Name: 6-FLUORO-2-METHYL-4-CHROMANONE
• Synonyms: fluoromethylchromanone;6-FLUORO-2-METHYL-4-CHROMANONE;6-Fluoro-2-methylchroman-4-one 97%;6-Fluoro-2-methyl-4-chromanone97%;2,3-Dihydro-6-fluoro-2-methyl-4H-1-benzopyran-4-one;6-Fluoro-2-methyl-2,3-dihydro-4H-chromen-4-one;6-fluoro-2-methylchroman-4-one
• CAS NO: 88754-96-5
• Molecular Formula: C₁₀H₉FO₂
• Molecular Weight: 180.18
• Mol File: 88754-96-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 71 °C
• Boiling Point: 121.7 °C
• Flash Point: 284 °C at 760 mmHg
• Appearance: /
• Density: 1.217 g/cm³
• CAS DataBase Reference: 6-FLUORO-2-METHYL-4-CHROMANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUORO-2-METHYL-4-CHROMANONE(88754-96-5)
• EPA Substance Registry System: 6-FLUORO-2-METHYL-4-CHROMANONE(88754-96-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-51
• Hazardous Substances Data: 88754-96-5(Hazardous Substances Data)

Usage

General Description

6-Fluoro-2-methyl-4-chromanone is a chemical compound with the molecular formula C10H9FO2. It is a synthetic organic compound with a fluorine atom attached to the carbon chain, and a methyl group and a chromanone ring structure. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds due to its unique structure and reactivity. It may also have potential medicinal properties, although further research is needed to fully understand its potential applications. Additionally, it is important to handle this chemical with care, as it may have potential hazards and should be used in a controlled environment by trained professionals.

Upstream product

• 371-41-5 4-Fluorophenol 
• 107-93-7 (E)-but-2-enoic acid 
• 123-75-1 pyrrolidine 
• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 75-07-0 acetaldehyde 
• 3724-65-0 2-butenoic acid 

Downstream Products

• 111477-58-8 ((2R,4R)-6-Fluoro-4-hydroxy-2-methyl-chroman-4-yl)-acetic acid ethyl ester 
• 890840-47-8 C₁₁H₁₂FNO₂ 
• 118260-10-9 C₁₀H₁₀FNO₂ 
• 111477-59-9 ((2R,4R)-6-Fluoro-4-hydroxy-2-methyl-chroman-4-yl)-acetic acid 
• 82319-87-7 C₁₂H₁₁FN₂O₃ 
• 102916-95-0 (2R,4S)-6-fluoro-2-methylspiro[chroman-4,4’-imidazolidine]-2’,5’-dione 
• 82319-87-7 C₁₂H₁₁FN₂O₃ 
• 82319-87-7 C₁₂H₁₁FN₂O₃ 

Relevant articles and documents

Hydantoin Bioisosteres. In Vivo Active Hydroxy Acetic Acid Aldose Reductase Inhibitors

The hypothesis that clinical side effects of the aldose reductase inhibitor (ARI) sorbinil were related to its hydantoin ring led to a bioisosteric analysis and replacement of the hydantoin by a spiro hydroxy acetic acid moiety as in 40.These hydroxy acids, compared to hydantoins, showed a similar potency increase on chroman 2-methyl substitution, a similar orthogonal relationship of acidic to aromatic moieties, and similar ARI enantioselectivity.In this series the six-membered spiro hydroxy acetic acid anion array is a bioisostere for a spiro hydantoin anion and leads to ARIs with excellent in vivo activity.In vitro and in vivo activity was improved over 40 by chroman cis 2-methylation as in 4 and by aromatic 6,7-halogen substitution.Compounds with the best acute in vivo activity in rats were compared for chronic in vivo activity.The highest tissue levels and best chronic in vivo activities were found in the racemic 6,7-dichloro and 6-fluoro-7-chloro analogues 18 and 23.ARI activity was enantioselective for 58 and 60, the 2R,4R-enantiomers of 18 and 23. 7-Chloro-6-fluoro-cis-4-hydroxy-2(R)-methyl-chroman-4-acetic acid (60) was selected for phase 1 clinical trials and did not exhibit sorbinil-like hypersensitivity side effects.

Hydroxyacetic acid derivatives for the treatment of diabetic complications

Racemic and chiral (2R,4R)-4-c-hydroxy-2-4-(substituted)chroman(and thiochroman)-4-acetic acids and their pharmaceutically acceptable salts, their use in the treatment of diabetic complications and intermediates therefor.