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Usage

Uses

Used in Pharmaceutical Development:
5-Methoxy-1H-benzimidazole-2-carboxylic acid is used as a key intermediate in the synthesis of pharmaceutical agents for various therapeutic applications. Its unique structure allows for the development of drugs that can modulate specific biological pathways, offering potential benefits in treating a range of diseases.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 5-Methoxy-1H-benzimidazole-2-carboxylic acid serves as a valuable compound for research and development activities. Its chemical properties and potential interactions with biological targets make it an interesting subject for studies aimed at understanding its mechanisms of action and optimizing its pharmaceutical potential.
Used in Drug Discovery:
5-Methoxy-1H-benzimidazole-2-carboxylic acid is utilized in drug discovery processes to identify and develop new therapeutic agents. Its presence in compound libraries and its reactivity in chemical reactions facilitate the exploration of novel drug candidates with improved efficacy, selectivity, and safety profiles.
While the specific applications and functions of 5-Methoxy-1H-benzimidazole-2-carboxylic acid are still under investigation, its role in the pharmaceutical industry and medicinal chemistry research is significant, with the potential to contribute to the advancement of new treatments and therapies.

InChI:InChI=1/C9H8N2O3/c1-14-5-2-3-6-7(4-5)11-8(10-6)9(12)13/h2-4H,1H3,(H,10,11)(H,12,13)

Upstream product

• 102-51-2 4-methoxy-1,2-phenylenediamine 
• 1016163-41-9 5-methoxy-1H-benzoimidazole-2-carboxylic acid methyl ester 
• 20033-99-2 (5-methoxy-1H-benzimidazole-2-yl)-methanol 
• 59548-39-9 4-methoxyphenylene-1,2-diamine dihydrochloride 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 420137-33-3 6-hydroxy-1H-benzimidazole-2-carboxylic acid 

Relevant academic research and scientific papers

Synthesis and evaluation of selected benzimidazole derivatives as potential antimicrobial agents

A library of 53 benzimidazole derivatives, with substituents at positions 1, 2 and 5, were synthesized and screened against a series of reference strains of bacteria and fungi of medical relevance. The SAR analyses of the most promising results showed that the antimicrobial activity of the compounds depended on the substituents attached to the bicyclic heterocycle. In particular, some compounds displayed antibacterial activity against two methicillin-resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentrations (MICs) comparable to the widely-used drug ciprofloxacin. The compounds have some common features; three possess 5-halo substituents; two are derivatives of (S)-2-ethanaminebenzimidazole; and the others are derivatives of one 2-(chloromethyl)-1Hbenzo[ d]imidazole and (1H-benzo[d]imidazol-2-yl)methanethiol. The results from the antifungal screening were also very interesting: 23 compounds exhibited potent fungicidal activity against the selected fungal strains. They displayed equivalent or greater potency in their MIC values than amphotericin B. The 5-halobenzimidazole derivatives could be considered promising broad-spectrum antimicrobial candidates that deserve further study for potential therapeutic applications.

Synthesis and in vitro opioid receptor functional antagonism of analogues of the selective kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1- {[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl) -1,2,3,4-tetrahydro-3-is

In previous structure-activity relationship (SAR) studies, we identified (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1- piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3- isoquinolinecarboxamide (JDTic, 1) as the first poten

New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation

We report the development of the novel N-substituted benzimidazole 11 as a potent and selective human formyl peptide receptor-like 1 (hFPRL1) agonist. This compound and its less active enantiomer 12 were identified as useful tools for studying receptor function in vitro.

Octahydropyrrolo[3,4-C]pyrrole derivatives

The present invention relates to octahydropyrrolo[3,4-c]pyrrole derivatives of formula (I): and to processes for the preparation thereof, compositions containing the same and the uses thereof.