887572-76-1

Upstream product

• 108-46-3 recorcinol 
• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 
• 878672-65-2 4-methyl-2-oxo-2H-benzopyran-7-yltrifluoromethanesulfonate 
• 93131-78-3 4-methyl-2-oxo-2H-chromen-7-yl-1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 
• 371-40-4 4-fluoroaniline 

Relevant academic research and scientific papers

4-Methyl-7-Amino/Amido Coumarin Derivatives as Potential Antimicrobials and Antioxidants

An array of previously synthesized 4-methyl-7-amino and amido coumarins 4a–u has been screened for their antimicrobial and antioxidant properties. Some of the compounds exhibited promising antibacterial and antifungal activities (MIC ranging from 4–64 μg/

A rapid and modified approach for C-7 amination and amidation of 4-methyl-7-nonafluorobutylsulfonyloxy coumarins under microwave irradiation

A facile, efficient and reliable access for the synthesis of an array of 4-methyl-7-(alkyl/aryl/heteroaryl) amino and amido coumarins has been developed by treating 4-methyl-7-nonafluorobutylsulfonyloxy coumarin with various amines and pyridones in presence of a catalyst combination of Pd2(dba) 3/xantphos under microwave irradiation. Nonaflates coupled efficiently to give the diaryl amines in acceptable to excellent yields whereas the corresponding triflate was unstable, yielding the detriflated product as well as the hydrolyzed product as competing side products along with the desired product. The wide bite angle (108°) of xantphos, employment of Cs 2CO3 as a mild base and the utilization of TBAF3H 2O as an additive proved to be key for success of the reaction.