887576-06-9

Usage

Derivative of indole

A heterocyclic aromatic organic compound

Carboxylic acid functional group

Located at the 6 position of the indole ring

3-Formyl group

A carbon atom doubly bonded to an oxygen atom and bonded to a hydrogen atom, located at the 3 position of the indole ring

Chemical and pharmaceutical applications

Used in various applications due to its unique structure and potential reactivity

Building block in synthesis

Used as a building block in the synthesis of complex organic molecules

Upstream product

• 133831-28-4 methyl 3-formyl-6-indolecarboxylate 

Downstream Products

• 1056002-08-4 6-(4-phenyl-piperidine-1-carbonyl)-1H-indole-3-carbaldehyde 
• 1056000-53-3 [3-(4-cyclobutyl-piperazine-1-ylmethyl)-1H-indol-6-yl]-(4-phenyl-piperidin-1-yl)-methanone 

Relevant academic research and scientific papers

Indole- and benzothiophene-based histamine H3 antagonists

Previous research on histamine H3 antagonists has led to the development of a pharmacophore model consisting of a central phenyl core flanked by two alkylamine groups. Recent investigation of the replacement of the central phenyl core with heteroaromatic fragments resulted in the preparation of novel 3,5-, 3,6- and 3,7-substituted indole and 3,5-substituted benzothiophene analogs that demonstrate good to excellent hH3 affinities. Select analogs were profiled in a rat pharmacokinetic model.

INDOLE AND BENZOTHIOPHENE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR

Certain substituted indole and benzothiophene compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.