887584-04-5

Basic information

• Product Name: 3-(2-pyridin-2-ylvinyl)quinoxalin-2(1H)-one
• Synonyms: 3-(2-pyridin-2-ylvinyl)quinoxalin-2(1H)-one
• CAS NO: 887584-04-5
• Molecular Formula: C15H11N3O
• Molecular Weight: 249.26734
• Mol File: 887584-04-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(2-pyridin-2-ylvinyl)quinoxalin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-pyridin-2-ylvinyl)quinoxalin-2(1H)-one(887584-04-5)
• EPA Substance Registry System: 3-(2-pyridin-2-ylvinyl)quinoxalin-2(1H)-one(887584-04-5)

Safety Data

• Hazardous Substances Data: 887584-04-5(Hazardous Substances Data)

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 14003-34-0 3-methyl-2-oxo-1,2-dihydroquinoxaline 

Relevant articles and documents

Malononitrile-activated synthesis and anti-cholinesterase activity of styrylquinoxalin-2(1: H)-ones

Herein, we report a base-free malononitrile activated condensation of 3-methylquinoxaline-2(1H)-one (3MQ) 1 with aryl aldehydes 3a-3ad for synthesis of styrylquinoxalin-2(1H)-ones (SQs) 4a-4ad with excellent yields. In this reaction, malononitrile activates the aldehyde via Knoevenagel condensation towards reaction with 3MQ 1 and gets liberated during the course of reaction to yield the desired SQs 4a-4ad. The SQs were evaluated for in vitro cholinesterase inhibition and 4n was found to display a mixed type of inhibition of AChE, which was supported by molecular modelling studies. This study has led to the discovery of a new chemotype for cholinesterase inhibition which might be useful in finding a remedy for Alzheimer's disease.