887587-15-7

Basic information

• Product Name: 3-ETHYLAMINO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 3-ETHYLAMINO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;TERT-BUTYL 3-(ETHYLAMINO)PYRROLIDINE-1-CARBOXYLATE;3-(Ethylamino)-1-pyrrolidinecarboxylic acid tert-butyl ester;3-Ethylamino-pyrrolidine-1-Carbocylic acid tert-butyl ester
• CAS NO: 887587-15-7
• Molecular Formula: C₁₁H₂₂N₂O₂
• Molecular Weight: 214.3
• Mol File: 887587-15-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 287℃
• Flash Point: 128℃
• Appearance: /
• Density: 1.01
• PKA: 10.22±0.20(Predicted)
• CAS DataBase Reference: 3-ETHYLAMINO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ETHYLAMINO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(887587-15-7)
• EPA Substance Registry System: 3-ETHYLAMINO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(887587-15-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 887587-15-7(Hazardous Substances Data)

Usage

General Description

3-Ethylamino-pyrrolidine-1-carboxylic acid tert-butyl ester is a complex organic chemical compound. 3-ETHYLAMINO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is most often used in the field of scientific research as a reagent in various biochemical reactions. The structure of this compound includes both a pyrrolidine ring, which is a basic nitrogen-containing five-member ring structure, and a carboxylic acid ester group, which is known for its ability to participate in reactions that form or break bonds at the oxygen atom. The molecular formula of this compound is C12H25N2O2. As with many other chemicals of its kind, it should be handled with care to avoid any harmful reactions or effects.

Upstream product

• 325775-36-8 tert-butyl 3-{[(benzyloxy)carbonyl]amino}-1-pyrrolidinecarboxylate 
• 186550-13-0 3-amino-1-(t-butoxycarbonyl)pyrrolidine 
• 75-07-0 acetaldehyde 
• 147081-49-0 (R)-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1271572-15-6 3-(4-chloro-phenyl)-1-ethyl-1-pyrrolidin-3-yl-urea 

Relevant articles and documents

Discovery of a novel bicyclic compound, DS54360155, as an orally potent analgesic without mu-opioid receptor agonist activity

We synthesized derivatives of a natural alkaloid, conolidine, and evaluated these derivatives in the acetic acid-induced writhing test and formalin test in ddY mice after oral administration. As a result, we identified (5S)-6-methyl-1,3,4,5,6,8-hexahydro-7H-2,5-methano[1,5]diazonino[7,8-b]indol-7-one sulfate salt, 15a (DS54360155), with a unique and original bicyclic skeleton, as an analgesic more potent than conolidine. Moreover, 15a did not exhibit mu-opioid receptor agonist activity.

3-amino nafoxidine-containing quinazoline ketone PARP (Poly Adenosine Diphosphate Ribose Polymerase)-1/2 inhibitor as well as preparation method, medicinal composition and application thereof

The invention discloses a novel 3-amino nafoxidine-containing quinazoline-2,4(1H, 3H)-diketone PARP-1/2 (Poly Adenosine Diphosphate Ribose Polymerase) inhibitor as well as a preparation method, a medicinal composition and application thereof. Specifically, the invention relates to a 3-amino nafoxidine-containing quinazoline-2,4(1H, 3H)-diketone derivative and a medicinal salt thereof of formula (I) as shown in the specification, a preparation method thereof, a composition with one or more such compounds, preparation of the compounds, and application thereof in preparing medicines for preventing and/or treating PARP-1/2 related diseases.

Chemokine receptor antagonists and methods of use thereof

Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof.