88759-59-5

Upstream product

• 32807-28-6 Methyl 4-chloroacetoacetate 
• 86728-93-0 methyl (S)-4-chloro-3-hydroxybutanoate 

Downstream Products

• 1621326-19-9 C₂₈H₂₉N₃O₃S 
• 892861-34-6 methyl (3S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-(methoxymethoxy)butanoate 
• 223466-77-1 methyl (3S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-hydroxybutanoate 

Relevant academic research and scientific papers

Method for preparing levorotatory oxiracetam crystal form II through pH method

The invention relates to a preparation method of a levorotatory oxiracetam crystal form II. The method comprises the steps of adopting S-4-chlorine-3-hydroxybutyrate and sodium azide as starting raw materials for preparing to obtain high-purity (S)-4-hydroxy-2 oxo-1-pyrrolidine acetamide; using acetic acid/ammonium hydroxide for preparing to obtain the (S)-4-hydroxy-2 oxo-1-pyrrolidine acetamide crystal from II through a pH method. The optical purity is 99.9 percent or above, and the product quality of the (S)-4-hydroxy-2 oxo-1-pyrrolidine acetamide crystal from II is greatly improved.

Preparation method for (S)-oxiracetam

The invention provides a preparation method for (S)-oxiracetam. The preparation method comprises the following steps: (1) with S-4-chloro-3-hydroxy butyrate as an initial raw material, subjecting the initial raw material and an azido reaction agent to an azido reaction so as to obtain an intermediate I; (2) subjecting the intermediate I to a reduction reaction so as to obtain an intermediate II; (3) subjecting the intermediate II and halogenated acetate to a condensation reaction so as to obtain an intermediate III; (4) subjecting the intermediate III to a ring closure reaction so as to obtain an intermediate IV; and (4) carrying out an aminolysis reaction on the intermediate IV so as to obtain the target product (S)-oxiracetam. The preparation method can prepare the (S)-oxiracetam product with ideal yield of at least more than 38%, and a novel synthetic route is opened up for (S)-oxiracetam.

Biocatalytic cascade for the synthesis of enantiopure β-azidoalcohols and β-hydroxynitriles

A three-step, two-enzyme, one-pot reaction sequence starting from prochiral a-chloroketones leading to enantiopure (3- azidoalcohols and (3-hydroxynitriles is described. Asymmetric bioreduction of a-chloroketones by hydrogen transfer catalysed by an alcohol dehydrogenase (ADH) established the stereogenic centre in the first step to furnish enantiopure chlorohydrin intermediates. Subsequent biocatalysed ring closure to the epoxide and nucleophilic ring opening with azide, N3-, or cyanide, CN-, both catalysed by a nonselective halohydrin dehalogenase (Hhe) proceeded with full retention of configuration to give enantiopure (-azidoalcohols and (3-hydroxynitriles, respectively. Both enantiomers of various optically pure (-azidoalcohols and (-hydroxynitriles were synthesised.