892861-34-6

Basic information

• Product Name: methyl (3S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-(methoxymethoxy)butanoate
• Synonyms: methyl (3S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-(methoxymethoxy)butanoate
• CAS NO: 892861-34-6
• Molecular Weight: 397.428
• Mol File: 892861-34-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl (3S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-(methoxymethoxy)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (3S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-(methoxymethoxy)butanoate(892861-34-6)
• EPA Substance Registry System: methyl (3S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-(methoxymethoxy)butanoate(892861-34-6)

Safety Data

• Hazardous Substances Data: 892861-34-6(Hazardous Substances Data)

Upstream product

• 42876-57-3 4-(1-benzofuran-2-yl)benzoyl chloride 
• 88759-59-5 methyl (3S)-4-azido-3-hydroxybutanoate 
• 88759-60-8 (S)-4-amino-3-hydroxybutyric acid methyl ester 
• 130403-84-8 methyl (3S)-3-hydroxy-4-{[(4-methylphenyl)sulfonyl]oxy}butanoate 
• 90414-36-1 methyl (3S)-3,4-dihydroxybutyrate 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 617-55-0 dimethyl (S)-malate 
• 98437-24-2 benzofuran-2-boronic acid 
• 69976-44-9 ethyl 4-(1-benzofuran-2-yl)benzoate 
• 36078-98-5 4-(Benzofuran-2-yl)benzoic acid 
• 223466-77-1 methyl (3S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-hydroxybutanoate 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 223466-80-6 (3S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-(methoxymethoxy)butanoic acid 
• 892861-35-7 (2E)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}but-2-enoic acid 

Relevant articles and documents

Design and synthesis of novel metalloproteinase inhibitors

A series of N-benzoyl 4-aminobutyric acid hydroxamate analogs were synthesized and evaluated as matrix metalloproteinase inhibitors. Synthetic work was focused on the chemical modification of the 4-aminobutyric acid part using easily available starting materials. As such, chemical modification was carried out using commercially available starting materials such as 4-aminobutyric acid, (+)- and (-)-malic acid, and d- and l-glutamic acid derivatives. Among the compounds tested, N-[4-(benzofuran-2-yl)benzoyl] 4-amino-4S-hydroxymethylbutyric acid hydroxamates derived from l-glutamic acid demonstrated more potent inhibitory activity against MMP-2 and MMP-9 compared with the corresponding 2S-hydroxy analogs or 3S-hydroxy analogs, respectively, which were derived from (-)-malic acid. Structure-activity relationship study is presented.