1304599-02-7Relevant articles and documents
Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1
Venier, Olivier,Pascal, Cécile,Braun, Alain,Namane, Claudie,Mougenot, Patrick,Crespin, Olivier,Pacquet, Franois,Mougenot, Cécile,Monseau, Catherine,Onofri, Bénédicte,Dadji-Fa?hun, Rommel,Leger, Céline,Ben-Hassine, Majdi,Van-Pham, Thao,Ragot, Jean-Luc,Philippo, Christophe,Güssregen, Stefan,Engel, Christian,Farjot, Géraldine,Noah, Lionel,Maniani, Karima,Nicola?, Eric
, p. 2244 - 2251 (2011/05/15)
A High Throughput Screening campaign allowed the identification of a novel class of ureas as 11β-HSD1 inhibitors. Rational chemical optimization provided potent and selective inhibitors of both human and murine 11β-HSD1 with an appropriate ADME profile an