887601-41-4Relevant academic research and scientific papers
Thermal cyclization of 1,2-dialkynylimidazoles to imidazo[1,2-a]pyridines
Nadipuram, Asha K.,Kerwin, Sean M.
, p. 3798 - 3808 (2006)
Thermolysis of 1,2-dialkynylimidazoles in chlorinated solvents leads to 5-chloroimidazo[1,2-a]-pyridine products, which are also formed in DMF containing 1 equiv of HCl. Deuterium labeling of the starting dialkynylimidazoles indicates that reaction may proceed by multiple pathways, depending upon conditions and substituents. Dialkynylimidazoles can also give rise to 5-diethylamino-substituted imidazopyridines when the thermolysis is carried out in the presence of diethylamine.
