887616-73-1

Upstream product

• 93-89-0 benzoic acid ethyl ester 
• 1015-28-7 dimethyl (2-oxo-2-phenylethyl)phosphonate 
• 434-45-7 2,2,2-Trifluoroacetophenone 
• 146801-38-9 (E)-4,4,4-trifluoro-1,3-diphenyl-2-buten-1-one 

Downstream Products

• 887616-75-3 (S)-(E)-4,4,4-trifluoro-1,3-diphenyl-2-butenyl acetate 
• 1020171-83-8 (R)-4,4,4-trifluoro-1,3-diphenylbutan-1-one 
• 165801-15-0 (S)-3,3,3-trifluoro-2-phenylpropan-1-ol 

Relevant academic research and scientific papers

Base-promoted isomerization of CF3-containing allylic alcohols to the corresponding saturated ketones under metal-free conditions

Following to the computational expectation, our previously reported intriguing 1,3-proton shift of 4,4,4-trifluorobut-2-yn-1-ols was successfully extended to the 4,4,4-trifluorobut-2-en-1-ol system under metal-free conditions to afford the corresponding saturated ketones in high to excellent chemical yields using such a convenient and easy-to-handle base as DBU at the toluene refluxing temperature, and utilization of the corresponding optically active substrates unambiguously demonstrated that this transformation proceeded in a highly stereoselective fashion.

One-pot relay reduction-isomerization of β-trifluoromethylated-α,β-unsaturated ketones to chiral β-trifluoromethylated saturated ketones over combined catalysts in aqueous medium

Despite great achievements obtained in tandem reactions, a solution for the incompatible nature of bimetal complexes participating in a multi-step catalytic process is still an unmet challenge. Herein, we utilize a functionalized periodic mesoporous organ

Palladium-catalyzed regio- and stereoselective formate reduction of fluorine-containing allylic mesylates. A new entry for the construction of a tertiary carbon attached with a fluoroalkyl group

The regioselective palladium-catalyzed formate reduction of γ-fluoroalkylated allylic esters is described. Reduction of the allylic esters under the influence of palladium with a monodentate phosphine ligand proceeded preferentially at the γ position, the corresponding reduction products with a fluoroalkyl group at the tertiary carbon being afforded in high yields. When the chiral allylic ester was employed, complete chirality transfer was observed, leading to the optically active materials in high yields.