887623-58-7

Upstream product

• 887624-70-6 N-(3,4-dimethylisoxazol-5-yl)piperazine-1-carboxamide 
• 887625-49-2 1-(2,4-difluorophenyl)-2-thiocyanatoethanone 
• 399-53-1 2,4-difluorobenzaldehyde 
• 887625-51-6 tert-butyl 4-[4-(2,4-difluorophenyl)thiazol-2-yl]piperazine-1-carboxylate 
• 19947-75-2 5-amino-3,4-dimethylisoxazol 
• 887625-50-5 2-bromo-4-(2,4-difluorophenyl)thiazole 
• 102429-07-2 2-bromo-2',4'-difluoroacetophenone 
• 887624-58-0 2,2,2-trichloroethyl (3,4-dimethylisoxazol-5-yl)carbamate 
• 887625-52-7 4-(2,4-difluorophenyl)-2-(piperazin-1-yl)thiazole 

Relevant academic research and scientific papers

A 2-thiocyano HYPNONE derivatives method for the preparation of

The invention discloses a method for preparing 2-sulfur cyano acetophenone derivatives. The method for preparing the 2-sulfur cyano acetophenone derivatives comprises the following steps: dissolving styrene derivatives and ammonium thiocyanate in a solvent, and reacting at 20-30 DEG C to obtain 2-sulfur cyano acetophenone derivatives. According to the method for preparing the 2-sulfur cyano acetophenone derivatives, the styrene derivatives are taken as starting materials; the raw materials are easily available and various in type; products prepared by the method have various in type, can be directly used and can also be used for other further reactions; meanwhile, the method is mild in reaction conditions and simple in reaction operation and post-processing process; an accelerant does not need to be added; the production process meets the green and chemical requirements, is relatively high in yield and is suitable for large-scale production.

Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors

A series of piperazine ureas was designed, synthesized, and evaluated for their potential as novel orally available fatty acid amide hydrolase (FAAH) inhibitors that are therapeutically effective against pain. We carried out an optimization study of the l