887641-63-6

Upstream product

• 99-91-2 para-chloroacetophenone 
• 7099-88-9 4-chlorophenylglyoxylic acid 
• 100-39-0 benzyl bromide 
• 4640-66-8 p-chlorobenzoylacetonitrile 
• 100-51-6 benzyl alcohol 
• 35249-73-1 benzyl chlorooxalate 
• 873-77-8 (4-chlorphenyl)magnesium bromide 

Downstream Products

• 1042740-59-9 benzyl 2-(4-chlorophenyl)-2-hydroxy-phenylacetate 
• 1449335-96-9 C₂₈H₂₆ClNO₆S 
• 1449336-15-5 C₂₂H₁₈ClNO₄S 

Relevant academic research and scientific papers

Visible Light Promotes Decyanation Esterification Reaction of β - Ketonitriles with Dioxygen and Alcohols to α-Ketoesters

A green and mild method has been developed for the conversion of β-ketonitriles into α-ketoesters under catalyst-free conditions. A plausible mechanism is that visible light promotes singlet oxygen generation to form the products through oxidative C-H bond functionalization and C-C σ -bond cleavage.

Pd(OAc)2-Catalyzed Asymmetric Hydrogenation of α-Iminoesters

An efficient Pd(OAc)2-catalyzed asymmetric hydrogenation of α-iminoesters was realized for the first time at 1 atm hydrogen pressure and room temperature. Pd(OAc)2, a less expensive Pd salt with low toxicity, was found to be the most suitable catalyst precursor rather than Pd(TFA)2 which is usually the catalyst of choice for homogeneous asymmetric hydrogenation. The chiral α-arylglycine fragments are widely found in many chiral products and bioactive molecules.

Highly chemo-, enantio-, and regioselective synthesis of α,α-disubstituted furanones by Cu-catalyzed conjugate addition

A highly chemo-, enantio-, and regioselective synthesis of furanones bearing an α,α-disubstituted quaternary stereogenic center is reported. The Cu-catalyzed enantioselective conjugate addition of organoaluminum reagents to unsaturated ketoesters at room temperature and subsequent lactonization took place. Synthetic transformations of furanones represent facile approaches to various cyclic or acyclic compounds bearing a quaternary stereogenic center. Selective chemistry: A highly chemo-, enantio-, and regioselective synthesis of furanones bearing an α,α-disubstituted quaternary stereogenic center is reported (see scheme). Cu-catalyzed enantioselective conjugate addition of organoaluminum reagents to unsaturated ketoesters at room temperature and subsequent lactonization took place.

Enantioselective rhodium-catalyzed addition of arylboronic acids to α-ketoesters

(Chemical Figure Presented) Rhodium catalysis: The first example of a catalytic asymmetric addition of arylboronic acids to α-ketoesters was realized by using a chiral RhI-spirophosphite ligand complex in aqueous solvent to provide tertiary α-hydroxyesters in good yields with high enantioselectivities (see scheme; DCE = 1,2-dichloroethane).