88768-66-5

Upstream product

• 88851-66-5 N-benzyl-3(S)-(3-methoxyphenyl)piperidine hydrochloride 
• 450416-70-3 (-)-(S)-tert-butyl 3-(3-methoxyphenyl)piperidine-1-carboxylate 

Downstream Products

• 89874-49-7 3(S)-(3-methoxyphenyl)-N-methylpiperidine 
• 89874-67-9 S-3-(3-Methoxyphenyl-N-ethyl)piperidine 
• 79412-38-7 (S)-3-Piperidin-3-yl-phenol; hydrobromide 
• 79412-66-1 1-[(S)-3-(3-Methoxy-phenyl)-piperidin-1-yl]-butan-1-one 
• 791738-64-2 3(S)-(3-methoxyphenyl)-N-isopropylpiperidine 
• 89874-71-5 (S)-3-(3-hydroxyphenyl)-N-methylpiperidine 
• 89874-73-7 (S)-3-(3-hydroxyphenyl)-N-ethylpiperidine 
• 146798-10-9 N-n-butyl-3(S)-(3-methoxyphenyl)piperidine 

Relevant academic research and scientific papers

Ligand-controlled β-selective C(sp3)-H arylation of N-Boc-piperidines

We report a general palladium-catalyzed β-arylation of Boc-piperidines, which yields a variety of valuable 3-arylpiperidines in a simple and direct manner. The β- vs. α-arylation selectivity was controlled by the ligand, with flexible biarylphosphines providing mainly the desired β-arylated products whereas more rigid biarylphosphines mainly furnished the more classical α-arylated products. The computed reaction mechanism (DFT), studied from the common α-palladated intermediate, indicated that the reductive elimination steps leading to the α- and β-arylated products are selectivity-determining. Moreover, the experimental trend obtained with different ligands was well reproduced by the calculations.

Resolved 3-(3-Hydroxyphenyl)-N-n-propylpiperidine and Its Analogues: Central Dopamine Receptor Activity

Seven enantiomeric pairs of N-alkyl analogues of 3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP, 12) have been synthesized and evaluated pharmacologically (biochemistry and behavior) in order to examine their ability to interact with central dopamine (DA