450416-70-3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 450416-68-9 (3S)-1-[(1S)-2-hydroxy-1-phenylethyl]-3-(3-methoxyphenyl)piperidine 
• 2398-37-0 3-methoxyphenyl bromide 
• 75844-69-8 t-butyl piperidinecarboxylate 
• 684215-27-8 bis-(3-methoxyphenyl)zinc 
• 450416-61-2 methyl 4-(3-methoxyphenyl)-5-oxopentanoate 
• 65292-99-1 2-(3-methoxyphenyl)acetaldehyde 
• 3105-95-1 pipecolinic acid 
• 450416-64-5 (3S,8S,8aS)-8-(3-methoxyphenyl)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 
• 450416-60-1 1-[(E)-2-(3-Methoxy-phenyl)-vinyl]-pyrrolidine 

Downstream Products

• 88768-66-5 (+)-3-(3-methoxyphenyl)piperidine hydrochloride 
• 88784-37-6 (+)-(S)-3-(3-methoxyphenyl)piperidine 

Relevant academic research and scientific papers

Stereoselective synthesis of (?)-3-PPP through palladium-catalysed unactivated C(sp3)–H arylation at the C-3 position of L-pipecolinic acid

An efficient route for the preparation of (?)-3-PPP(preclamol) using the highly stereoselective palladium-catalysed C(sp3)-H arylation and radical decarboxylation reaction as the key steps is described. The chiral center at the C-3 position of

Synthesis method of Preclamol intermediate

The invention discloses a synthesis method of a Preclamol intermediate, comprising the following steps: carrying out a condensation reaction between N-tert-butoxycarbonyl-piperidin-3-carboxylic acid and N-hydroxy phthalimide to prepare (N-Butoxycarbonyl-p

Ligand-controlled β-selective C(sp3)-H arylation of N-Boc-piperidines

We report a general palladium-catalyzed β-arylation of Boc-piperidines, which yields a variety of valuable 3-arylpiperidines in a simple and direct manner. The β- vs. α-arylation selectivity was controlled by the ligand, with flexible biarylphosphines providing mainly the desired β-arylated products whereas more rigid biarylphosphines mainly furnished the more classical α-arylated products. The computed reaction mechanism (DFT), studied from the common α-palladated intermediate, indicated that the reductive elimination steps leading to the α- and β-arylated products are selectivity-determining. Moreover, the experimental trend obtained with different ligands was well reproduced by the calculations.

Dynamic kinetic resolution of racemic γ-aryl-δ-oxoesters. Enantioselective synthesis of 3-arylpiperidines

Cyclodehydration of racemic γ-aryl-δ-oxoesters with (R)- or (S)-phenylglycinol stereoselectively affords bicyclic δ-lactams, in a process that involves a dynamic kinetic resolution. Subsequent reduction of these lactams leads to enantiopure 3-arylpiperidines. Starting from racemic aldehyde esters, this short sequence has been applied to the synthesis of (R)-3-phenylpiperidine and the antipsychotic drug (-)-3-PPP (an (S)-3-arylpiperidine), whereas starting from racemic ketone esters enantiopure cis-2-alkyl-3-arylpiperidines are prepared.