88783-22-6Relevant academic research and scientific papers
Synthesis of β-aminoketones and construction of highly substituted 4-piperidones by mannich reaction induced by persistent radical cation salts
Jia, Xiao-Dong,Wang, Xiao-E.,Yang, Cai-Xia,Huo, Cong-De,Wang, Wen-Juan,Ren, Yan,Wang, Xi-Cun
supporting information; experimental part, p. 732 - 735 (2010/04/02)
A Mannich reaction of imines and ketones induced by persistent radical cation salts was Investigated, and a series of Mannich bases, β-amlnoketones, were synthesized. A novel cyclization to form the 4-piperidone skeleton was achieved In a tandem process. The reaction can be rationalized as a radical cation process supported by various evidence.
Mannich-type reactions of aromatic aldehydes, anilines, and methyl ketones in fluorous biphase systems created by rare earth (III) perfluorooctane sulfonates catalysts in fluorous media
Yi, Wen-Bin,Cai, Chun
, p. 1515 - 1521 (2008/09/16)
Rare earth (III) perfluorooctane sulfonates (RE(OPf)3) catalyze the three-component Mannich-type reactions of different ketones with various aromatic aldehydes and aromatic amines in fluorous media to give various β-arylamino ketones in good yields. By simple separation of the fluorous phase containing only catalyst, reaction can be repeated several times.
The Mannich reaction of butanone, aromatic aldehydes and aromatic amines
Lin,Junhua,Huangshu,Qilin
, p. 2109 - 2117 (2007/10/02)
Under the catalysis of small amount of concentrated hydrochloric acid, the Mannich reaction of butanone, aromatic aldehydes and aromatic amines can be carried out directly at 0-20°C. Twelve corresponding Mannich bases (1), 1-aryl-1-arylamino-3-pentanones, were prepared in high yields.
