88791-04-2

Basic information

• Product Name: Carbamothioic acid, dimethyl-, S-(2-formyl-6-methoxyphenyl) ester
• CAS NO: 88791-04-2
• Molecular Formula: C11H13NO3S
• Molecular Weight: 239.295
• Mol File: 88791-04-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Carbamothioic acid, dimethyl-, S-(2-formyl-6-methoxyphenyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamothioic acid, dimethyl-, S-(2-formyl-6-methoxyphenyl) ester(88791-04-2)
• EPA Substance Registry System: Carbamothioic acid, dimethyl-, S-(2-formyl-6-methoxyphenyl) ester(88791-04-2)

Safety Data

• Hazardous Substances Data: 88791-04-2(Hazardous Substances Data)

Upstream product

• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 88791-03-1 O-(2-formyl-6-methoxyphenyl)-N,N-dimethylthiocarbamate 

Downstream Products

• 88791-05-3 2-mercapto-3-methoxybenzaldehyde 
• 1462267-57-7 (Z)-1-(3-methoxy-2-methylthiophenyl)-2-(3,4,5-trimethoxyphenyl)ethene 
• 1462267-54-4 (E)-3-(3-methoxy-2-methylthiophenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enoic acid 
• 1312608-59-5 C₄₃H₅₂N₈O₆S 
• 1312610-32-4 C₃₉H₄₆N₆O₄S 
• 1312610-31-3 C₂₇H₃₄B₂O₄S 
• 1312610-30-2 C₁₇H₁₀F₆O₆S₃ 
• 1312610-29-9 C₁₅H₁₂O₂S 
• 1312610-28-8 C₁₇H₁₆O₂S 
• 1312608-58-4 C₄₂H₅₀N₈O₆S 
• 1312610-06-2 C₂₈H₂₈N₆S 
• 1312610-05-1 C₃₈H₄₄N₆O₄S 
• 1312610-04-0 C₂₆H₃₂B₂O₄S 
• 1312610-03-9 C₁₆H₈F₆O₆S₃ 

Relevant articles and documents

Synthesis, crystal structure and conformational analysis of an unexpected [1,5]dithiocine product of aminopyridine and thiovanillin

The condensation reaction of 2-mercapto-3-methoxybenzaldehyde with 3-aminopyridine afforded an unexpected N-alkylated [1,5]dithiocine instead of the N-salicylideneaniline. The proposed mechanism for this condensation involves a strong intramolecular hydro

Ambient-Temperature Newman-Kwart Rearrangement Mediated by Organic Photoredox Catalysis

The Newman-Kwart rearrangement is perhaps the quintessential method for the synthesis of thiophenols from the corresponding phenol. However, the high thermal conditions required for the rearrangement of the requisite O-aryl carbamothioates often leads to decomposition. Herein, we present a general strategy for catalysis of O-aryl carbamothioates to S-aryl carbamothioates using catalytic quantities of a commercially available organic single-electron photooxidant. Importantly, this reaction is facilitated at ambient temperatures.

Substituted 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[b] thiophene derivatives as potent tubulin polymerization inhibitors

The central role of microtubules in cell division and mitosis makes them a particularly important target for anticancer agents. On our early publication, we found that a series of 2-(3′,4′,5′-trimethoxybenzoyl)-3- aminobenzo[b]thiophenes exhibited strong antiproliferative activity in the submicromolar range and significantly arrested cells in the G2-M phase of the cell cycle and induced apoptosis. In order to investigate the importance of the amino group at the 3-position of the benzo[b]thiophene skeleton, the corresponding 3-unsubstituted and methyl derivatives were prepared. A novel series of inhibitors of tubulin polymerization, based on the 2-(3,4,5-trimethoxybenzoyl)-benzo[b]thiophene molecular skeleton with a methoxy substituent at the C-4, C-5, C-6 or C-7 position on the benzene ring, was evaluated for antiproliferative activity against a panel of five cancer cell lines, for inhibition of tubulin polymerization and for cell cycle effects. Replacing the methyl group at the C-3 position resulted in increased activity compared with the corresponding 3-unsubstituted counterpart. The structure-activity relationship established that the best activities were obtained with the methoxy group placed at the C-4, C-6 or C-7 position. Most of these compounds exhibited good growth inhibition activity and arrest K562 cells in the G2-M phase via microtubule depolymerization.