88791-05-3

Upstream product

• 88791-04-2 S-(2-formyl-6-methoxyphenyl)-N,N-dimethylthiocarbamate 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 88791-03-1 O-(2-formyl-6-methoxyphenyl)-N,N-dimethylthiocarbamate 
• 7217-59-6 2-Methoxybenzenethiol 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 88791-07-5 7-methoxybenzothiophene-2-carboxylic acid 
• 88791-06-4 (2-formyl-6-methoxyphenylthio)acetic acid 
• 500897-91-6 (2-tert-butoxycarbonylamino-propionylamino)-(2-formyl-6-methoxy-phenylsulfanyl)-acetic acid tert-butyl ester 
• 500897-94-9 (2-tert-butoxycarbonylamino-propionylamino)-(2-difluoromethyl-6-methoxy-phenylsulfanyl)-acetic acid tert-butyl ester 
• 77898-35-2 7-hydroxybenzo[b]thiophene 
• 88791-08-6 7-methoxybenzothiophene 
• 88791-12-2 4-bromo-7-methoxybenzothiophene 
• 1239336-87-8 C₂₈H₃₀N₄O₈S₂ 
• 1239890-20-0 (7-methoxybenzo[b]thiophen-2-yl)(3,4,5-trimethoxyphenyl)methanone 
• 1312610-01-7 C₁₆H₁₄O₂S 
• 1312610-02-8 C₁₄H₁₀O₂S 
• 1312610-03-9 C₁₆H₈F₆O₆S₃ 
• 1312610-04-0 C₂₆H₃₂B₂O₄S 
• 1312610-05-1 C₃₈H₄₄N₆O₄S 

Relevant academic research and scientific papers

Synthesis, crystal structure and conformational analysis of an unexpected [1,5]dithiocine product of aminopyridine and thiovanillin

The condensation reaction of 2-mercapto-3-methoxybenzaldehyde with 3-aminopyridine afforded an unexpected N-alkylated [1,5]dithiocine instead of the N-salicylideneaniline. The proposed mechanism for this condensation involves a strong intramolecular hydro

Design, synthesis, and biological evaluation of novel combretastatin A-4 thio derivatives as microtubule targeting agents

A series of novel combretastatin A-4 (CA-4) thio derivatives containing different molecular cores, namely α-phenylcinnamic acids (core 1), (Z)-stilbenes (core 2), 4,5-disubstituted oxazoles (core 3), and 4,5-disubstituted N-methylimidazoles (core 4), as cis-restricted analogues were designed and synthesized. They were selected with the use of a parallel virtual screening protocol including the generation of a virtual combinatorial library based on an elaborated synthesis protocol of CA-4 analogues. The selected compounds were evaluated for antiproliferative activity against a panel of six human cancer cell lines (A431, HeLa, MCF7, MDA-MB-231, A549 and SKOV) and two human non-cancer cell lines (HaCaT and CCD39Lu). Moreover, the effect of the test compounds on the inhibition of tubulin polymerization in vitro was estimated. In the series studied here, oxazole-bridged analogues exhibited the most potent antiproliferative activity. Compounds 23a, 23e, and 23i efficiently inhibited tubulin polymerization with IC50 values of 0.86, 1.05, and 0.85 μM, respectively. Thio derivative 23i, when compared to its oxygen analogue 23j, showed a 5-fold higher inhibitory impact on tubulin polymerization. Compounds 23e and 23i, which showed both best cytotoxic and antitubulin activity, were further studied in terms of their effect on cell cycle distribution and proapoptotic activity. Compound 23e induced a statistically significant block of the cell cycle at the G2/M phase in A431, HaCaT, HeLa, MCF-7, MDA-MB-231, and SKOV-3 cells to an extent comparable to that observed in CA-4. In HeLa and SKOV-3 cells incubated with 23i, a concentration-dependent block of the G2/M phase was observed. The proapoptotic effect of 23e and 23i in A431, HaCaT, MCF-7, MDA-MB-231, and SKOV-3 was demonstrated with ELISA assay and double staining with Annexin V-FITC/PI. The results indicated that compound 23e and 23i may serve as novel lead compounds in research on more effective anticancer agents.

NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION

The embodiments provide compounds of the general Formulae I, II, III, IV, or V as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

Synthesis of Ag+-selective dipalladium(II) metallohost based on O-alkyloxime bis(N2SO) ligands

Novel bis(N2SO) ligands 2a (= H4L2a) and 2b (= H4L2b) comprising O-alkyloxime, thiophenol, and phenol moieties were synthesized. The complexation of H4L 2a and H4L2b with palladium(II) acetate afforded the dinuclear metallohosts [L2aPd2] and [L 2bPd2], which have a recognition site consisting of two sulfur and four oxygen donor atoms. The metallohost [L2bPd 2] strongly binds Ag+ to give [(L2bPd 2)2Ag]+, whereas no detectable interaction between [L2bPd2] and hard metal cations (Na+, Ca2+, Y3+, La3+, and Lu3+) was observed. Copyright Taylor & Francis Group.

Substituted 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[b] thiophene derivatives as potent tubulin polymerization inhibitors

The central role of microtubules in cell division and mitosis makes them a particularly important target for anticancer agents. On our early publication, we found that a series of 2-(3′,4′,5′-trimethoxybenzoyl)-3- aminobenzo[b]thiophenes exhibited strong antiproliferative activity in the submicromolar range and significantly arrested cells in the G2-M phase of the cell cycle and induced apoptosis. In order to investigate the importance of the amino group at the 3-position of the benzo[b]thiophene skeleton, the corresponding 3-unsubstituted and methyl derivatives were prepared. A novel series of inhibitors of tubulin polymerization, based on the 2-(3,4,5-trimethoxybenzoyl)-benzo[b]thiophene molecular skeleton with a methoxy substituent at the C-4, C-5, C-6 or C-7 position on the benzene ring, was evaluated for antiproliferative activity against a panel of five cancer cell lines, for inhibition of tubulin polymerization and for cell cycle effects. Replacing the methyl group at the C-3 position resulted in increased activity compared with the corresponding 3-unsubstituted counterpart. The structure-activity relationship established that the best activities were obtained with the methoxy group placed at the C-4, C-6 or C-7 position. Most of these compounds exhibited good growth inhibition activity and arrest K562 cells in the G2-M phase via microtubule depolymerization.

SUBSTITUTED 4-ALKOXYOXAZOL DERIVATIVES AS PPAR AGONISTS

The present invention relates to compounds of formula (I) wherein R1 to R8 and n are as defined in the description and claims, and pharmaceutically acceptable salts and esters thereof. The compounds are useful for the treatment of diseases such as diabetes.

7-Substituted Benzothiophenes and 1,2-Benzisothiazoles. Part 1. Hydroxy- or Methoxy-derivatives

Readily available 2-hydroxy-3-methoxybenzaldehyde (orthovanilin) is converted, via terminal rearrangement (Newman-Kwart) of the O-aryl-NN-dimethylthiocarbamate, into 2-mercapto-3-methoxybenzaldehyde (3).This thiol undergoes base-catalysed condensation wit