88791-26-8

Basic information

• Product Name: 7-methoxy-1,2-benzisothiazole
• CAS NO: 88791-26-8
• Molecular Weight: 165.216
• Mol File: 88791-26-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 199.9±22.0 °C(Predicted)
• Density: 1.268±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 7-methoxy-1,2-benzisothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 7-methoxy-1,2-benzisothiazole(88791-26-8)
• EPA Substance Registry System: 7-methoxy-1,2-benzisothiazole(88791-26-8)

Safety Data

• Hazardous Substances Data: 88791-26-8(Hazardous Substances Data)

Upstream product

• 54881-49-1 2-chloro-3-methoxy benzaldehyde 
• 100-53-8 phenylmethanethiol 
• 103438-88-6 2-fluoro-3-methoxybenzaldehyde 

Relevant articles and documents

Microbial metabolites and derivatives targeted at inflammation and bone diseases therapy: Chemistry, biological activity and pharmacology

Microbial metabolites have attracted increasing interest as a source of therapeutics and as probes for biological mechanisms. New microbial metabolites and derivatives targeted at inflammation and bone disease therapy have been identified by focusing on prostaglandin release, osteoblast differentiation and immune cell functions. These modulators of inflammatory processes and bone disease contribute to our understanding of biological mechanisms and support identification of the therapeutic potential of drug lead candidates. The present review describes recent advances in the chemistry and analysis of inhibitors of prostaglandin release or other functional molecules of immune cells, as well as inducers of osteoblast differentiation, including biological and pharmacological activities.

PROPANAMINE DERIVATIVES AS SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITORS

There is provided a heretoaryloxy/thio 3-substituted propanamine compound of formula (I) wherein A is selected from -O- and -S-; X is selected from phenyl optionally substituted with up to 5 substituents each independently selected from halo, C1-C4 alkyl and C1-C4 alkoxy, thienyl optionally substituted with up to 3 substituents each independently selected from halo and C1-C4 alkyl, and C2-C8 alkyl, C2-C8 alkenyl, C3-C8 cycloalkyl and C4-C8 cycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n- where n is 0, 1 or 2, -CF3, -CN and -CONH2; Y is selected from dihydrobenzothienyl, benzothiazolyl, benzoisothiazolyl, quinolyl, isoquinolyl, naphthyridyl, and thienopyridyl, each of which may be optionally substituted with up to 4 or, where possible, up to 5 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n- where n is 0, 1 or 2, nitro, acetyl, -CF3, -SCF3 and cyano; Z is selected from H, OR3 or F, wherein R3 is selected from H, C1-C6 alkyl and phenyl C1-C6 alkyl; R1 and R2 are each independently H or C1-C4 alkyl; and pharmaceutically acceptable salts thereof.

Nematicidal compositions

Benzisothiazoles of the general formula I STR1 in which the group RO-- is in one of the positions of the benzene ring and R is a pure or halogenated hydrocarbon radical which is aliphatic or cycloaliphatic, saturated or unsaturated, are active ingredients in crop protection products. They can be used for controlling nematodes which are parasites of plants.