887946-58-9

Upstream product

• 19082-37-2 1-hydroxy-1-phenyl-4-pentyne 
• 5390-04-5 pent-1-yn-5-ol 
• 18498-59-4 4-pentyn-1-al 
• 887946-74-9 (1-bromo-pent-4-ynyl)-benzene 
• 887946-59-0 2,2,6,6-tetramethyl-1-(1-phenylpent-4-ynyloxy)piperidine 

Relevant academic research and scientific papers

Isonitrile trapping reactions under thermolysis of alkoxyamines for the synthesis of quinolines

An efficient tandem radical process comprising a thermal alkoxyamine homolysis, an isonitrile trapping reaction, a 5-exo-trig cyclization, and a homolytic aromatic substitution leads to substituted dihydroquinolines. Depending on the substituent R1, oxidation to dihydro-1H-cyclopenta- [b]quinolines (for R1 = aryl) or tautomerization to tetrahydro-1H-cyclopenta[b]quinolines (for R1 = CO2Me, CN) occurs. The heterocycles are obtained in moderate to good yields. Upon using microwave-induced heating, the reaction time can be shortened from 3 days to 30 min.