887946-74-9

Upstream product

• 88071-01-6 2-phenyl-5-hexynoic acid 
• 19082-37-2 1-hydroxy-1-phenyl-4-pentyne 
• 5390-04-5 pent-1-yn-5-ol 
• 18498-59-4 4-pentyn-1-al 

Downstream Products

• 887946-59-0 2,2,6,6-tetramethyl-1-(1-phenylpent-4-ynyloxy)piperidine 
• 887946-58-9 1-((E)-5-bromo-1-phenylpent-4-enyloxy)-2,2,6,6-tetramethyl-piperidine 

Relevant academic research and scientific papers

Silver-Catalyzed Decarboxylative Bromination of Aliphatic Carboxylic Acids

The silver-catalyzed Hunsdiecker bromination of aliphatic carboxylic acids is described. With Ag(Phen)2OTf as the catalyst and dibromoisocyanuric acid as the brominating agent, various aliphatic carboxylic acids underwent decarboxylative bromination to provide the corresponding alkyl bromides under mild conditions. This method not only is efficient and general but also enjoys wide functional group compatibility. An oxidative radical mechanism involving Ag(II) intermediates is proposed.

Isonitrile trapping reactions under thermolysis of alkoxyamines for the synthesis of quinolines

An efficient tandem radical process comprising a thermal alkoxyamine homolysis, an isonitrile trapping reaction, a 5-exo-trig cyclization, and a homolytic aromatic substitution leads to substituted dihydroquinolines. Depending on the substituent R1, oxidation to dihydro-1H-cyclopenta- [b]quinolines (for R1 = aryl) or tautomerization to tetrahydro-1H-cyclopenta[b]quinolines (for R1 = CO2Me, CN) occurs. The heterocycles are obtained in moderate to good yields. Upon using microwave-induced heating, the reaction time can be shortened from 3 days to 30 min.