888010-02-4

Usage

Uses

Used in Bioconjugation:
Propargyl-PEG4-CH2CO2tBu is used as a bioconjugation agent for the attachment of azide-containing biomolecules to other molecules or surfaces. Its reactivity with azide compounds under copper catalysis allows for the formation of stable triazole linkages, facilitating the creation of bioconjugates for various applications.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Propargyl-PEG4-CH2CO2tBu is used as a component in drug delivery systems. Its ability to react with azide-containing drug molecules enables the development of targeted drug delivery systems, improving the efficacy and bioavailability of therapeutic agents.
Used in Material Science:
In the field of material science, Propargyl-PEG4-CH2CO2tBu is used as a functionalizing agent for the modification of surfaces and materials. Its reactivity with azide compounds allows for the attachment of various functional groups, enabling the development of new materials with tailored properties for specific applications.
Used in Chemical Synthesis:
Propargyl-PEG4-CH2CO2tBu is used as a synthetic intermediate in the synthesis of complex organic molecules. Its reactivity with azide compounds and the ability to deprotect the t-butyl group under acidic conditions make it a valuable building block for the construction of diverse molecular structures.

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 208827-90-1 O-propargyl triethylene glycol 
• 107-59-5 tert-Butyl chloroacetate 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 

Downstream Products

• 1115614-24-8 C₃₄H₄₃BF₂N₂O₆ 
• 1694731-93-5 C₁₁H₁₈O₆ 
• 1115614-26-0 C₅₂H₅₁BF₂N₂O₁₀ 
• 1310827-39-4 C₅₀H₅₁BF₂N₂O₆ 
• 1115614-25-9 C₃₄H₄₁BF₂I₂N₂O₆ 

Relevant academic research and scientific papers

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

DIMERIC IMMUNO-MODULATORY COMPOUNDS AGAINST CEREBLON-BASED MECHANISMS

Disclosed are small molecules against cereblon to enhance effector T cell function. Methods of making these molecules and methods of using them to treat various disease states are also disclosed.

STAT DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE

The present disclosure relates to bifunctional compounds, which find utility as modulators of SMARCA2 or BRM (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a ligand that binds to the Von Hippel-Lindau E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

A "click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation

Proteolysis targeting chimeras (PROTACs) are bispecific molecules containing a target protein binder and an ubiquitin ligase binder connected by a linker. By recruiting an ubiquitin ligase to a target protein, PROTACs promote ubiquitination and proteasomal degradation of the target protein. The generation of effective PROTACs depends on the nature of the protein/ligase ligand pair, linkage site, linker length, and linker composition, all of which have been difficult to address in a systematic way. Herein, we describe a "click chemistry" approach for the synthesis of PROTACs. We demonstrate the utility of this approach with the bromodomain and extraterminal domain-4 (BRD4) ligand JQ-1 (3) and ligase binders targeting cereblon (CRBN) and Von Hippel-Lindau (VHL) proteins. An AlphaScreen proximity assay was used to determine the ability of PROTACs to form the ternary ligase-PROTAC-target protein complex and a MSD assay to measure cellular degradation of the target protein promoted by PROTACs.

An iterative route to "decorated" ethylene glycol-based linkers

Iterative copper-catalyzed cycloadditions of azides to alkynes were used to join functionalized triethylene glycol molecules to give "linkers" of defined lengths equipped with several different end-group functionalities. The Royal Society of Chemistry 200