888019-69-0Relevant articles and documents
Robust preparation of novel imidazo[5,1-b][1,3,4]oxadiazoles
Tran, Tuan P.,Patel, Nandini,Samas, Brian,Schwarz, Jacob B.
supporting information; experimental part, p. 5063 - 5066 (2010/04/04)
Cyclodehydration of amino acid-derived acyl hydrazide amides 2 to the corresponding oxadiazoles was followed by a second dehydration event, smoothly furnishing the novel imidazo[5,1-b][1,3,4]oxadiazole motif 1.
Synthesis and biological activity of novel amino acid-(N'-benzoyl) hydrazide and amino acid-(N'-nicotinoyl) hydrazide derivatives
Khattab, Sherine N.
, p. 1218 - 1228 (2007/10/03)
The coupling reaction of benzoic acid and nicotinic acid hydrazides with N-protected L-amino acids including valine, leucine, phenylalanine, glutamic acid and tyrosine is reported. The target compounds, N-Boc-amino acid-(N'-benzoyl)- and N-Boc-amino acid-(N'-nicotinoyl) hydrazides 5a-5e and 6a-6e were prepared in very high yields and purity using N-[(dimethylamino)-1H- 1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methyl-methanaminium hexafluorophosphate N-oxide (HATU) as coupling reagent. The antimicrobial activity of the Cu and Cd complexes of the designed compounds was tested. The products were deprotected affording the corresponding amino acid-(N'-benzoyl) hydrazide hydrochloride salts (7a-7e) and amino acid-(N'-nicotinoyl) hydrazide hydrochloride salts (8a-8e). These compounds and their Cu and Cd complexes were also tested for their antimicrobial activity. Several compounds showed comparable activity to that of ampicillin against S. aureus and E. coli.