88807-02-7

Upstream product

• 285-67-6 Cyclopentene oxide 
• 285-67-6 (1S,5R)-6-Oxa-bicyclo[3.1.0]hexane 
• 142-29-0 cyclopentene 
• 125356-51-6 (1S,2S)-trans-2-azidocyclopentanol 
• 260065-78-9 Acetic acid (1R,2S)-2-azido-cyclopentyl ester 
• 1449391-76-7 (1S,2R)-cis-2-azidocyclopentyl p-nitrobenzoate 
• 110716-79-5 (1R,2R)-trans-2-azidocyclopentanol 
• 260065-68-7 (1R,2R)-trans-2-azidocyclopentyl acetate 
• 108-05-4 vinyl acetate 
• 756874-86-9 (1S,2S)-2-azido-cyclopentyl butyrate 
• 4648-54-8 trimethylsilylazide 

Downstream Products

• 125356-51-6 (1S,2S)-trans-2-azidocyclopentanol 
• 260065-68-7 (1R,2R)-trans-2-azidocyclopentyl acetate 
• 110716-79-5 (1R,2R)-trans-2-azidocyclopentanol 
• 168749-07-3 (1R,2S)-cis-2-azidocyclopentanol 
• 260065-79-0 (1S,2R)-cis-2-azidocyclopentanol 
• 260065-78-9 Acetic acid (1R,2S)-2-azido-cyclopentyl ester 

Relevant academic research and scientific papers

Copper-catalyzed ring-opening reactions of alkyl aziridines with b2 pin2: Experimental and computational studies

The possibility to form new C–B bonds with aziridines using diboron derivatives con-tinues to be a particularly challenging field in view of the direct preparation of functionalized β-aminoboronates, which are important compounds in drug discovery, being a bioisostere of β-aminoacids. We now report experimental and computational data that allows the individua-tion of the structural requisites and of reaction conditions necessary to open alkyl aziridines using bis(pinacolate)diboron (B2 pin2 ) in a regioselective nucleophilic addition reaction under copper catalysis.

CuO supported 1-methyl-3-(3-(trimethoxysilyl) propyl) imidazolium chloride (MTMSP-Im/Cl) nanoparticles as an efficient simple heterogeneous catalysts for synthesis of β-azido alcohols

In the present study, CuO supported 1-methyl-3-(3-(trimethoxysilyl) propyl) imidazolium chloride (MTMSP-Im/Cl) is synthesized as a novel, efficient and eco-friendly heterogeneous nanocatalyst. This nanocatalyst was applied for selective ring opening of ep

Acetic acid functionalized ionic liquid systems: An efficient and recyclable catalyst for the regioselective ring opening of epoxides with NaN3

In the present study, an environmentally benign, efficient, and solvent-free procedure was developed for the synthesis of 1,2-azidoalcohols by the regioselective ring opening of some epoxides with sodium azide (NaN3) in the presence of an aceti

1-(1-Alkylsulfonic)-3-methylimidazolium chloride as a reusable Br?nsted acid catalyst for the regioselective azidolysis of epoxides under solvent-free conditions

In this study, 1-(1-alkylsulfonic)-3-methylimidazolium chloride as a new, green, and reusable Br?nsted acid catalyst was prepared. In this protocol, we used for the regioselective ring-opening reactions of various epoxiodes with sodium azide to afford the

Design, synthesis and shape evaluation of cerium iron oxide nanorods for an epoxide opening reaction through azide addition

Uniform nanorod structured Ce1-xFexO2 has been synthesized through a simple urea hydrolysis method without any surfactant. The prepared nanorods of Ce0.75Fe0.25O2 are well clear and uniform

ERK INHIBITORS

The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are ERK2 inhibitors. The invention also provides a pharmaceutical composition comprising an effective amount of at least one compound of Formula (I) and a pharmaceutically acceptable carrier. The invention also provides a pharmaceutical composition comprising an effective amount of at least one compound of Formula (I) and an effective amount of at least one other pharmaceutically active ingredient (such as, for example, a chemotherapeutic agent), and a pharmaceutically acceptable carrier.

Lanthanide-based coordination polymers as promising heterogeneous catalysts for ring-opening reactions

This work presents the synthesis and structural characterization of Eu3+- and Tb3+-based coordination polymers starting from a Co3+-based metalloligand offering appended arylcarboxylic acid groups. Both coordination polymers function as reusable heterogeneous catalysts for ring-opening reactions utilizing amines, alcohols, thiols, and azides as the nucleophiles. The catalytic results illustrate an excellent control over the regioselectivity whereas a filtration test and mechanistic studies substantiate Lewis-acid catalyzed activation of the epoxide during the reaction.

Catalytic transformation of esters of 1,2-azido alcohols into α-amido ketones

The esters of 1,2-azido alcohols were transformed into α-amido ketones without external oxidants through the Ru-catalyzed formation of N-H imines with the liberation of N2 followed by intramolecular migration of the acyl moiety. A wide range of α-amido ketones were obtained, and one-pot transformation into the corresponding oxazoles (or a thiazole) was demonstrated.

Glycerol functionalized imidazolium tri-cationic room temperature ionic liquids: Synthesis, properties and catalytic performance for 2-azidoalcohol synthesis from epoxide

Imidazolium based tri-cationic room temperature ionic liquid (RTILs) were synthesized and characterized, and their physicochemical properties such as thermal stability, viscosities and solubility were investigated. These ionic liquids exhibited excellent

Activation of carboxylic acids in asymmetric organocatalysis

Organocatalysis, catalysis using small organic molecules, has recently evolved into a general approach for asymmetric synthesis, complementing both metal catalysis and biocatalysis.1 Its success relies to a large extent upon the introduction of novel and generic activation modes.2 Remarkably though, while carboxylic acids have been used as catalyst directing groups in supramolecular transition-metal catalysis,3 a general and well-defined activation mode for this useful and abundant substance class is still lacking. Herein we propose the heterodimeric association of carboxylic acids with chiral phosphoric acid catalysts as a new activation principle for organocatalysis. This self-assembly increases both the acidity of the phosphoric acid catalyst and the reactivity of the carboxylic acid. To illustrate this principle, we apply our concept in a general and highly enantioselective catalytic aziridine-opening reaction with carboxylic acids as nucleophiles. Activation by dimerization: There is still no general activation mode for carboxylic acids in organocatalysis. The formation of heterodimers between chiral phosphoric acid diesters and carboxylic acids can be used to activate and direct reactivity of the latter in asymmetric reactions. This novel principle has been applied to the ring-opening desymmetrization and kinetic resolution of aziridines leading to valuable amino alcohols.