88826-07-7Relevant academic research and scientific papers
Synthesis of new phenolic compounds and biological evaluation as antiproliferative agents
Ibrahim, Marwa A,George, Riham F,Abou-Seri, Sahar M,El-Moghazy, Samir M
, p. 181 - 192 (2020)
New series of phenolic azomethine compounds in addition to 5-arylidene thiazolidinones are synthesized and screened for their anticancer activity against the brain cancer cell line SNB-75 and non-small lung cancer cells HOP-92. The azomethine derivative 12b is the most active compound against SNB-75 displaying an IC50 value of 0.14 μM. Compounds 7b, 16a and 27d display submicromolar activity against the HOP-92 cell line with IC50 values of 0.73, 0.74 and 0.81 μM, respectively. Moreover, studying the cytotoxic effects of the most active compounds against normal lung cells WI-38 revealed that compounds 7b, 16a and 27d showed high safety profiles as anticancer agents.
Synthesis, structure-activity relationships and preliminary mechanism study of N-benzylideneaniline derivatives as potential TLR2 inhibitors
Cai, Shaoyi,Zhu, Gengzheng,Cen, Xiaohong,Bi, Jingjie,Zhang, Jingru,Tang, Xiaoshan,Chen, Kun,Cheng, Kui
, p. 2041 - 2050 (2018/03/13)
Toll-like receptor 2 (TLR2) can recognize pathogen-associated molecular patterns to defense against invading organisms and has been represents an attractive therapeutic target. Until today, none TLR2 small molecule antagonist have been developed in clinic
