888281-83-2Relevant academic research and scientific papers
Synthesis of new substituted pyridine derivatives as potent anti-liver cancer agents through apoptosis induction: In vitro, in vivo, and in silico integrated approaches
Boraei, Ahmed T.A.,Eltamany, Elsayed H.,Ali, Ibrahim A.I.,Gebriel, Sara M.,Nafie, Mohamed S.
, (2021/04/27)
Liver cancer is the most common type of cancer in many countries. New studies and statistics show rising liver cancer worldwide, so it is essential to seek new agents for this type of cancer. PIM1 has an attractive target in the discovery of cancer medica
A microwave approach to the synthesis of certain 4-(substituted phenyl)-6-phenyl-3-cyano-2-pyridones
Marinkovic, Aleksandar,Mijin, Du?an,Mirkovic, Jelena,Maslak, Veselin,Kappe, C. Oliver
, p. 759 - 765 (2014/11/27)
A study of the synthesis of 4-(substituted phenyl)-6-phenyl-3-cyano- 2-pyridones from ethyl 2-cyano-3-(substituted phenyl) acrylates and acetophenone is presented. The 2-pyridones were obtained using conventional as well as microwave synthesis under solvent and solvent-free conditions in domestic and laboratory microwave ovens. The structure of the obtained pyridones was confirmed by m.p., FT-IR, NMR and UV data.
An efficient and facile multicomponent synthesis of 4,6-diarylpyridine derivatives under solvent-free conditions
El-Sayed, Hassan A.,Ouf, Nabil H.,Moustafa, Ahmed H.
, p. 407 - 412 (2014/02/14)
We present an efficient and facile synthesis of 4,6-diaryl-2-oxo-1,2- dihydropyridine-3-carbonitriles (5a-j) via a four-component system of aromatic aldehydes (1), acetophenones (2), ethyl cyanoacetate (3), and ammonium acetate (4). The short reaction tim
One-pot four component synthesis of 4, 6-disubstituted 3-cyano-2-pyridones in polyethylene glycol
Nalage, Santosh V.,Nikum, Ajay P.,Kalyankar, Mohan B.,Patil, Vijay S.,Patil, Umesh D.,Desale, Kamlesh R.,Patil, Shamkant L.,Bhosale, Sidhanath V.
experimental part, p. 406 - 410 (2011/04/12)
The reaction of ketone, aldehyde, ethyl cyanoacetate and ammonium acetate in polyethylene glycol-600 is reported. The reaction proceeds smoothly in the absence of catalyst to yield 2-Pyridones.
