88830-49-3Relevant academic research and scientific papers
On the Use of Carboxamidomethyl Esters in the Protease-Catalyzed Peptide Synthesis
Kuhl, Peter,Zacharias, Ute,Burckhardt, Helmut,Jakubke, Hans-Dieter
, p. 1195 - 1204 (1986)
Carboxyamidomethyl esters (CAM esters) of Z-and Boc-protected alanine and phenylalanine were prepared in order to investigate their usefulness as substrates for α-chymotrypsin- and papain-catalyzed hydrolysis and peptide synthesis reactions.The easy removal of the CAM-C-protecting group under mild conditions and dependent on the enzyme specificity was demonstrated.Examples are given for the protease-catalyzed synthesis of various peptide derivatives using CAM esters as C- and N-components in aqueous-organic media.Comparatively short reaction times were observed. - Key words: Carboxyamidomethyl ester as C-protecting group; Enzymatic deprotection; Peptide synthesis; α-Chymotrypsin- and Papain-catalyzed peptide bond formation
ON THE USE OF CARBOXAMIDOMETHYL ESTERS ( CAM ESTERS ) IN THE SYNTHESIS OF MODEL PEPTIDES. SCOPE AND LIMITATIONS
Martinez, Jean,Laur, Janine,Castro, Bertrand
, p. 739 - 744 (2007/10/02)
The usefulness of carboxamidomethyl esters ( CAM esters ) as a carboxyl protecting group for peptide synthesis was demonstrated.The synthesis of the chemotactic peptide For-Met-Leu-Phe-OH as well as the synthesis of Met-enkephalin using CAM ester as carbo
CARBOXAMIDOMETHYL ESTERS (CAM ESTERS) AS CARBOXYL PROTECTING GROUPS
Martinez, Jean,Laur, Jeanine,Castro, Bertrand
, p. 5219 - 5222 (2007/10/02)
The carboxamidomethyl esters (CAM esters) are proposed for carboxyl protection in peptide synthesis.Amino acid CAM ester derivatives were easily prepared and showed good stability in the deblocking conditions of other common protecting groups used in pept
