888318-85-2

Upstream product

• 6576-05-2 1-(4-fluorophenyl)-2-(4-pyridyl)ethanone 
• 888318-78-3 [5-(4-fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]-acetic acid methyl ester 
• 888318-83-0 [5-(4-fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]-acetic acid 
• 124-40-3 dimethyl amine 

Downstream Products

• 888318-89-6 {2-[5-(4-fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]-ethyl}-dimethyl-amine 
• 888318-92-1 5-(4-fluoro-phenyl)-2,5-dioxo-4-pyridin-4-yl-pentanoic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis and SAR Studies of diarylpyrrole anticoccidial agents

2-(4-Fluorophenyl)-3-(4-pyridinyl)-5-substituted pyrroles were prepared and evaluated as anticoccidial agents in both in vitro and in vivo assays. Among the compounds evaluated, the dimethylamine-substituted pyrrole 19a is the most potent inhibitor of Eimeria tenella PKG (cGMP-dependent protein kinase). Further SAR studies on the side chain of the 2-pyrrolidine nitrogen did not enhance in vivo anticoccidial activity.