888406-95-9Relevant academic research and scientific papers
Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: Improving metabolic stability and reducing ion channel activity
Fray, M. Jonathan,Fish, Paul V.,Allan, Gillian A.,Bish, Gerwyn,Clarke, Nick,Eccles, Rachel,Harrison, Anthony C.,Net, Jean-Loic Le,Phillips, Stephen C.,Regan, Nicola,Sobry, Cecile,Stobie, Alan,Wakenhut, Florian,Westbrook, Dominique,Westbrook, Simon L.,Whitlock, Gavin A.
scheme or table, p. 3788 - 3792 (2010/08/20)
New N-(1,2-diphenylethyl)piperazines 6 are disclosed as dual serotonin and noradrenaline reuptake inhibitors (SNRI) which may have potential in treating stress urinary incontinence (SUI). In this Letter, we present new data for SNRI PF-526014 (4) includin
N-(1,2-Diphenylethyl)piperazines: A new class of dual serotonin/noradrenaline reuptake inhibitor
Jonathan Fray,Bish, Gerwyn,Brown, Alan D.,Fish, Paul V.,Stobie, Alan,Wakenhut, Florian,Whitlock, Gavin A.
, p. 4345 - 4348 (2007/10/03)
The synthesis and structure-activity relationships of a novel series of piperazine derivatives as dual inhibitors of serotonin and noradrenaline reuptake is described. Two compounds possessed comparable in vitro profiles to the dual reuptake inhibitor dul
PIPERAZINE DERIVATIVES WHICH EXHIBIT ACTIVITY AS SEROTONIN AND NORADRENALINE RE-UPATKE INHIBITORS
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Page/Page column 54; 55, (2010/02/13)
A compound of formula (I), wherein R1 is H; R2 is aryl, het, C3-8cycloalkyl, C1-6alkyl, (CH2)zaryl or R4, wherein each of the cycloalkyl, aryl, het and R4 groups is op
